LRIG2 Antibody, Biotin conjugated

1. Study demonstrated that LRIG2 promoted the PDGFRBinduced proliferation of glioblastoma multiforme cells in vitro and in vivo through regulating the PDGFRB signalingmediated cell cycle progression. PMID: 30015847
2. Role of LRIG2 in cancer [review] PMID: 27628597
3. LRIG2 gene is overexpressed in invasive pituitary adenoma. PMID: 21823015
4. A subset of urofacial syndrome-affected individuals have biallelic mutations in LRIG2 PMID: 23313374
5. Cytoplasmic expression of LRIG2 is associated with meningiomas. PMID: 22484910
6. LRIG1 and LRIG2 expressions were seen in precancerous cervical epithelium and found to increase with increasing grade. PMID: 21632100
7. LRIG2 was found to be a glycoprotein with an molecular weight of 132 kDa, which was encoded by a gene on human chromosome 1p13 and its mRNA was present in all tissues analyzed. PMID: 15145052
8. LRIG proteins may have a role in epidermal homeostasis and psoriasis PMID: 18037903
9. This is the first report of an LRIG protein showing a negative effect on survival, suggesting that LRIG2 might have a function different from that of LRIG1, and possibly contributing to the etiology of oligodendroglioma. PMID: 18992012

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HGNC: 20889

OMIM: 608869

KEGG: hsa:9860

STRING: 9606.ENSP00000355396

UniGene: Hs.448972