LRIG3 Antibody, FITC conjugated

1. Role of LRIG3 in cancer [review] PMID: 27628597
2. This is the first time a haplotype on chromosome 12 containing sequence variants in the genes DCTN2, DNAH10, LRIG3, and MYO1A has been linked to an inherited neuropathy in humans. PMID: 26517670
3. LRIG3 functions as a tumor suppressor by attenuating EGFR signaling pathway. PMID: 25708990
4. LRIG3 plays an important role in Hela229 cell proliferation, apoptosis, and invasiveness. PMID: 26390694
5. The results on expression of other tumor markers suggest that LRIG3 is influenced by or influences a pattern of tumor markers in cancer and precancerous cells. PMID: 24998916
6. In conclusion, the over-expression of LRIG3 could influence the cell cycle and invasion, inhibit proliferation and induce apoptosis in the three bladder cancer cell lines. PMID: 23392718
7. Data indicate that Lrig3 opposes Lrig1 negative regulatory action and enhances ErbB receptors ERBB2, ERBB3 and ERBB4 stability. PMID: 23723069
8. High LRIG3 expression is associated with cervical adenocarcinoma progression. PMID: 23165628
9. Silencing LRIG3 inhibited the proliferation and promoted the apoptosis of bladder cancer T24 cells. PMID: 21505989
10. siRNA targeting LRIG3 gene shows a dramatic inhibitory effect on RNA transcription and protein expression, then promotes the proliferation and suppresses apoptosis of GL15 cells. PMID: 19224171
11. These results indicate that expression and sub-cellular localization of LRIG1-3 might be of importance in the pathogenesis and prognosis of astrocytic tumors. PMID: 16532360
12. Down-regulation of LRIG3 in HP75 pituitary adenoma is reported. PMID: 17393120
13. LRIG proteins may have a role in epidermal homeostasis and psoriasis PMID: 18037903
14. LRIG3 may be involved in the regulation of EGF receptor signaling, and serve as a tumor suppressor gene in the pathogenesis of glioma. PMID: 19200647
15. the expression of LRIG1-3 was evaluated in 51 human ependymomas and was found to be more highly expressed in supratentorial than in infratentorial ependymomas PMID: 19216216
16. Down-regulating LRIG3 gene expression can improve the proliferation of glioma GL15 cells. PMID: 19448407

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HGNC: 30991

OMIM: 608870

KEGG: hsa:121227

STRING: 9606.ENSP00000326759

UniGene: Hs.253736