LSM4 Antibody

Code CSB-PA013207GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
LSM4
Alternative Names
LSM4U6 snRNA-associated Sm-like protein LSm4 antibody; Glycine-rich protein antibody; GRP antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human LSM4
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.
Gene References into Functions
  1. Results show that the RGG domain of human Lsm4 stimulates processing bodies formation. Also, a novel interaction of the Lsm4 RGG domain with HAT1 and RBBP7 was discovered, leading to the possibility of a posttranslational modifications network involved in mRNP regulation. PMID: 27247266
  2. C-terminal extension of Lsm4 interacts directly with the histone mRNP, contacting both SLBP and 3'hExo. PMID: 24255165
  3. Data show that ICln159, a truncated ICln mutant, belongs to the pleckstrin homology (PH) domain family of proteins and interacts with LSm4, a protein involved in splicing and mRNA degradation. PMID: 15905169
  4. Gene induces transformed phenotype when overexpressed in a cancer breast cell line. PMID: 17178857
  5. LSm4 not only acts in RNA processing, but also as a co-factor in cell volume regulation. PMID: 19088440

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Subcellular Location
Nucleus.
Protein Families
SnRNP Sm proteins family
Database Links

HGNC: 17259

OMIM: 607284

KEGG: hsa:25804

STRING: 9606.ENSP00000469468

UniGene: Hs.515255

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