LSM4 Antibody

Datasheet

Code	CSB-PA013207HA01HU
Size	US$166
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Image	Western blot All lanes: LSM4 antibody at 2µg/ml Lane 1: A549 whole cell lysate Lane 2: K562 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 16 kDa Observed band size: 16 kDa Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA013207HA01HU at dilution of 1:200 Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA013207HA01HU at dilution of 1:200 Immunofluorescent analysis of Hela cells using CSB-PA013207HA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L) Immunofluorescent analysis of HepG2 cells using CSB-PA013207HA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) LSM4 Polyclonal antibody

Uniprot No.

Q9Y4Z0

Target Names

LSM4

Alternative Names

LSM4U6 snRNA-associated Sm-like protein LSm4 antibody; Glycine-rich protein antibody; GRP antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human U6 snRNA-associated Sm-like protein LSm4 protein (1-139AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The LSM4 Antibody (Product code: CSB-PA013207HA01HU) is Non-conjugated. For LSM4 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA013207HB01HU	LSM4 Antibody, HRP conjugated	ELISA
FITC	CSB-PA013207HC01HU	LSM4 Antibody, FITC conjugated
Biotin	CSB-PA013207HD01HU	LSM4 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.

Gene References into Functions

Results show that the RGG domain of human Lsm4 stimulates processing bodies formation. Also, a novel interaction of the Lsm4 RGG domain with HAT1 and RBBP7 was discovered, leading to the possibility of a posttranslational modifications network involved in mRNP regulation. PMID: 27247266
C-terminal extension of Lsm4 interacts directly with the histone mRNP, contacting both SLBP and 3'hExo. PMID: 24255165
Data show that ICln159, a truncated ICln mutant, belongs to the pleckstrin homology (PH) domain family of proteins and interacts with LSm4, a protein involved in splicing and mRNA degradation. PMID: 15905169
Gene induces transformed phenotype when overexpressed in a cancer breast cell line. PMID: 17178857
LSm4 not only acts in RNA processing, but also as a co-factor in cell volume regulation. PMID: 19088440

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Subcellular Location

Nucleus.

Protein Families

SnRNP Sm proteins family

Database Links

HGNC: 17259

OMIM: 607284

KEGG: hsa:25804

STRING: 9606.ENSP00000469468

UniGene: Hs.515255

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Email: [email protected]
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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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