LTB Antibody

Datasheet

Code	CSB-PA823426
Size	US$100
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Image	Immunohistochemical analysis of paraffin-embedded human-liver, antibody was diluted at 1:200 Immunohistochemical analysis of paraffin-embedded human-spleen, antibody was diluted at 1:200 Immunohistochemical analysis of paraffin-embedded human-spleen, antibody was diluted at 1:200
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

Q06643

Target Names

LTB

Alternative Names

LT beta antibody; LT-beta antibody; Ltb antibody; lymphotoxin beta antibody; Lymphotoxin-beta antibody; p33 antibody; TNF-C antibody; TNFC antibody; TNFC_HUMAN antibody; TNFSF3 antibody; Tumor necrosis factor C antibody; Tumor necrosis factor ligand superfamily member 3 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide from Human protein at AA range: 41-90

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Purification Method

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.

Form

Liquid

Tested Applications

IHC,ELISA

Recommended Dilution

Application	Recommended Dilution
IHC	1:50-300
ELISA	1:10000-20000

Protocols

Immunohistochemistry (IHC) Protocol
ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function

Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional.

Gene References into Functions

Combination of an EGFR tyrosine kinase inhibitor and a NF-kappaB inhibitor effectively suppressed cetuximab-resistant HNSCC and interfering with the EGFR-LTbeta interaction reverses resistance. PMID: 28196873
TNF is able to upregulate LT-beta expression in hepatic cells at the transcriptional level by the binding of NF-kappaB p50/p65 heterodimers and Ets1 to their respective sites in the LT-beta promoter. PMID: 22742857
The multifaceted character of lymphotoxin beta may be involved in inflammatory myopathies and muscular dystrophies. PMID: 22652080
Data show differential expression of interferon-gamma, TNFSF3, TNFSF10, TNFSF12 and PDGFbeta in CD8+, CD14+ and CD4+ cells. PMID: 21211989
Findings provide evidence of additional complexity in the transcriptional regulation of LTB with implications for coordinate expression of genes in this important genomic locus. PMID: 21248773
Heterotypic interaction between LTbeta-producing lymphocytes and responding fibroblast-like synoviocytes contributes to establishment of complex lymphoid microstructures. May be one element in susceptibility of synovial membrane to lymphoid organogenesis. PMID: 15248211
The identification of IL-6 and IL-1beta as activators of LT-beta supports their involvement in LT-beta signaling in liver regeneration associated with chronic liver damage. PMID: 15910501
Lymphotoxin (LT) beta receptor ligands LTalpha1 and -beta2 activate both the classical and noncanonical NF-kappa B pathways in human vascular endothelial cells and dermal microvascular endothelial cells in vitro. PMID: 18292573
LT-Beta may play a role in rheumatoid arthritis disease pathogenesis by contributing to a more intense inflammatory reaction in the synovium PMID: 18379788
blocking the lymphotoxin-beta receptor pathway results in ablation of the lymphoid organization in the NOD salivary glands and thus an improvement in salivary gland function. PMID: 19222863

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Subcellular Location

Membrane; Single-pass type II membrane protein.

Protein Families

Tumor necrosis factor family

Tissue Specificity

Spleen and thymus.

Database Links

HGNC: 6711

OMIM: 600978

KEGG: hsa:4050

STRING: 9606.ENSP00000410481

UniGene: Hs.376208

Promotions

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Email: [email protected]
Distributors Worldwide

Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

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Related pathways

NF-kappa B signaling pathway

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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