LTC4S Antibody

1. mutational and kinetic data, together with molecular simulations, suggest that phosphorylation of Ser(36) inhibits the catalytic function of LTC4S by interference with the catalytic machinery. PMID: 27365393
2. Biochemical and structural characterization of LTC4S mutants along with crystal structures of the wild type and mutated enzymes in complex with three product analogs, provide new insights to binding of substrates and product. PMID: 24366866
3. The results of our study failed to confirm whether the selected variants in LTC4S gene within the LT metabolism pathway contribute to platelet reactivity in a diabetic population treated with ASA. PMID: 23828562
4. Elevated levels of leukotriene C4 synthase mRNA distinguish a subpopulation of eosinophilic oesophagitis patients. PMID: 23889244
5. genetic association studies in population of Han Chinese in Eastern China: Data suggest that an SNP in LTC4S (rs730012) is associated with risk of ischemic stroke; carriers of C allele of rs730012 in LTC4S are most susceptible to ischemic stroke. PMID: 23079278
6. meta-analysis suggested that the -444A/C polymorphism in the LTC4S gene would be a risk factor for asthma in Caucasians and aspirin-tolerant populations PMID: 22884858
7. A significant association has been found between the -1072G/A (rs3776944) SNP in the LTC4S gene and atopic asthma in the family-based analysis. PMID: 22722751
8. The SNPs of ALOX(5)AP and LTC(4)S are associated with asthma. PMID: 21729626
9. investigation of catalytic mechanism of LTC4S: Data suggest that glutathione thiolate anion formation in LTC4S is not rate-limiting for overall reaction of leukotriene C4 production. Thiolate anion is stabilized by Arg104 at all three active sites. PMID: 22217203
10. Polymorphisms of the PTGDR and LTC4S influence responsiveness to leukotriene receptor antagonists in Korean children with asthma. PMID: 21307858
11. The catalytic architecture of leukotriene C4 synthase with two arginine residues. PMID: 21454538
12. The increased expression of LTC(4)S, together with the predominant formation of cysteinyl-leukotrienes and effects on MMPs production, suggests a mechanism by which LTs may promote matrix degradation in the AAA wall PMID: 21078989
13. Arginine 104 is a key catalytic residue in leukotriene C4 synthase. PMID: 20980252
14. In a Southwest Chinese Han population LTC(4)S A(-444)C polymorphism might be a determinant factor in the clinical response of asthma to leukotriene receptor antagonists. PMID: 19080532
15. no association between gene polymorphism and bronchial asthma in a Spanish population PMID: 20128419
16. Distinct roles of receptor phosphorylation, G protein usage, and mitogen-activated protein kinase activation on platelet activating factor-induced leukotriene C(4) generation PMID: 11934880
17. no relationship between the polymorphism and LTC4S activity in eosinophils, although LTC4S activities were significantly higher in patients with aspirin induced asthma than in patients with aspirin tolerant asthma PMID: 12063521
18. A(-444)C polymorphism of this gene and clinical response to pranlukast in Japanses patients with moderate asthma PMID: 12360108
19. C-to-A promoter polymorphism was associated with the increased presence of chronic hyperplastic eosinophilic sinusitis and the expression of cysteinyl leukotrienes PMID: 12589355
20. expression of LTC(4)S during normal and leukemic myelopoiesis and correlation with the activity of the disease-specific tyrosine kinase p210 BCR-ABL in CML myeloid cells. PMID: 12591277
21. Gene expression in mononuclear phagocytes is regulated by SP1 and SP3. PMID: 12664565
22. Data show that mucosal mast cells, and not eosinophils, were the dominating leukotriene C4 synthase-containing cells in both untreated and treated aspirin-tolerant asthma. PMID: 12816731
23. We further conclude that the A(-444)C polymorphism in the LTC(4) synthase gene probably contributes to asthma interpatient variability in montelukast-evoked changes in FE(NO)* and warrants further study. PMID: 14520724
24. independent of transcriptional activity, the C(-444) allele in the LTC(4) synthase gene is weakly associated with the asthma phenotype, but it is not related to disease severity or aspirin intolerance PMID: 15131571
25. calculated a projection map of recombinant human LTC(4) synthase at a resolution of 4.5 A by electron crystallography PMID: 15530365
26. leukotriene C4 synthase gene promoter polymorphism is associated with asthma and/or atopy PMID: 16024972
27. Glu 4 Lys amino acid substitution in the LTC4S might be associated with allergic diseases. PMID: 16211251
28. The C allele of the leukotriene C4 synthase (A-444C) polymorphism is associated with asthma phenotype or severity. PMID: 16675353
29. LTC4S plays a key role in the process of inflammation as the rate limiting enzyme in the conversion of arachidonic acid to cysteinyl-leukotrienes, important mediators of inflammatory responses. PMID: 17110605
30. The combination of 927T CYSLTR1 and -444A LTC4S was less common in male patients with asthma than in controls and the combination of 927C CYSLTR1 and -444A LTC4S was slightly more frequent in patients with asthma PMID: 17153879
31. The results of a case-control study aimed at investigating the association of MGST1 gene locus polymorphisms with colorectal cancer risk among Han Chinese are presented. PMID: 17483957
32. crystal structure of the human LTC4 synthase in its apo and GSH-complexed forms to 2.00 and 2.15 A resolution, respectively PMID: 17632546
33. atomic structure of human LTC4S in a complex with glutathione at 3.3 A resolution by X-ray crystallography PMID: 17632548
34. Leukotriene C(4) synthase -1072 AA genotype predict increased risk, whereas -444 CC genotype predict decreased risk of ischemic cerebrovascular disease. PMID: 18276912
35. Genetic variation in leukotriene pathway members and their receptors confer an increased risk of ischemic stroke in 2 independent populations PMID: 18323512
36. The combined study of polymorphisms in genes of the leukotriene pathway could explain the differences observed in the studies reported on polymorphism -444A < C LTC4S individually analysed. PMID: 19080797
37. LTC(4)S interacts in vitro with both FLAP and 5-LO and that these interactions involve distinct parts of LTC(4)S. PMID: 19233132
38. Leukotriene C4 synthase promoter genotypes influence risk of transient ischemic attack and ischemic stroke, but not risk of ischemic heart disease/coronary atherosclerosis, asthma, or chronic obstructive pulmonary disease. PMID: 19280718
39. Observational study of gene-gene interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 17924829
40. Clinical trial and meta-analysis of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 12968987

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HGNC: 6719

OMIM: 246530

KEGG: hsa:4056

STRING: 9606.ENSP00000292596

UniGene: Hs.706741