LZTR1 Antibody

Datasheet

Code	CSB-PA836674ESR1HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA836674ESR1HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA836674ESR1HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) LZTR1 Polyclonal antibody

Uniprot No.

Q8N653

Target Names

LZTR1

Alternative Names

Leucine zipper like regulator 1 antibody; Leucine zipper like transcription regulator 1 antibody; Leucine-zipper-like transcriptional regulator 1 antibody; LZTR-1 antibody; Lztr1 antibody; LZTR1_HUMAN antibody; MGC21205 antibody; TCFL2 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Leucine-zipper-like transcriptional regulator 1 protein (300-545AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates ubiquitination of Ras (K-Ras/KRAS, N-Ras/NRAS and H-Ras/HRAS). Is a negative regulator of RAS-MAPK signaling that acts by controlling Ras levels and decreasing Ras association with membranes.

Gene References into Functions

the malignancy risk in schwannomatosis is not well defined but may include an increased risk of malignant peripheral nerve sheath tumor in SMARCB1 Imaging protocols are also proposed for SMARCB1 and LZTR1 schwannomatosis and SMARCE1-related meningioma predisposition. PMID: 28620005
Nerve lesions and LZTR1 germline mutations in segmental schwannomatosis. PMID: 27472264
Data indicate that molecular analysis of leucine-zipper-like transcription regulator 1 (LZTR1) may contribute to the molecular characterization of schwannomatosis patients. PMID: 25335493
We show for the first time that an inherited mutation in PBRM1 predisposes to RCC. PMID: 25795793
Data confirm the relationship between mutations in LZTR1 and schwannomatosis. They indicate that germline mutations in LZTR1 confer an increased risk of vestibular schwannoma. PMID: 25480913
Germline loss-of-function mutations in LZTR1 predispose to an inherited disorder of multiple schwannomas. PMID: 24362817
LZTR-1 is the first BTB-kelch protein that exclusively localizes to the Golgi network PMID: 16356934

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Involvement in disease

Schwannomatosis 2 (SWNTS2); Noonan syndrome 10 (NS10)

Subcellular Location

Endomembrane system. Recycling endosome. Golgi apparatus.

Database Links

HGNC: 6742

OMIM: 600574

KEGG: hsa:8216

STRING: 9606.ENSP00000215739

UniGene: Hs.78788

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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