Recombinant Human Leucine-zipper-like transcriptional regulator 1 (LZTR1), partial

Code CSB-YP836674HU
MSDS
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Source Yeast
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Code CSB-EP836674HU
MSDS
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Source E.coli
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Code CSB-EP836674HU-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP836674HU
MSDS
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Source Baculovirus
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Code CSB-MP836674HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
LZTR1
Uniprot No.
Alternative Names
Leucine zipper like regulator 1; Leucine zipper like transcription regulator 1; Leucine-zipper-like transcriptional regulator 1; LZTR-1; Lztr1; LZTR1_HUMAN; MGC21205; TCFL2
Species
Homo sapiens (Human)
Protein Length
Partial
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates ubiquitination of Ras (K-Ras/KRAS, N-Ras/NRAS and H-Ras/HRAS). Is a negative regulator of RAS-MAPK signaling that acts by controlling Ras levels and decreasing Ras association with membranes.
Gene References into Functions
  1. the malignancy risk in schwannomatosis is not well defined but may include an increased risk of malignant peripheral nerve sheath tumor in SMARCB1 Imaging protocols are also proposed for SMARCB1 and LZTR1 schwannomatosis and SMARCE1-related meningioma predisposition. PMID: 28620005
  2. Nerve lesions and LZTR1 germline mutations in segmental schwannomatosis. PMID: 27472264
  3. Data indicate that molecular analysis of leucine-zipper-like transcription regulator 1 (LZTR1) may contribute to the molecular characterization of schwannomatosis patients. PMID: 25335493
  4. We show for the first time that an inherited mutation in PBRM1 predisposes to RCC. PMID: 25795793
  5. Data confirm the relationship between mutations in LZTR1 and schwannomatosis. They indicate that germline mutations in LZTR1 confer an increased risk of vestibular schwannoma. PMID: 25480913
  6. Germline loss-of-function mutations in LZTR1 predispose to an inherited disorder of multiple schwannomas. PMID: 24362817
  7. LZTR-1 is the first BTB-kelch protein that exclusively localizes to the Golgi network PMID: 16356934

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Involvement in disease
Schwannomatosis 2 (SWNTS2); Noonan syndrome 10 (NS10)
Subcellular Location
Endomembrane system. Recycling endosome. Golgi apparatus.
Database Links

HGNC: 6742

OMIM: 600574

KEGG: hsa:8216

STRING: 9606.ENSP00000215739

UniGene: Hs.78788

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