Ly75 Antibody

Code CSB-PA013251HA01MO
Size US$299
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Product Details

Full Product Name Rabbit anti-Mus musculus (Mouse) Ly75 Polyclonal antibody
Uniprot No. Q60767
Target Names Ly75
Alternative Names Ly75 antibody; Cd205 antibody; Lymphocyte antigen 75 antibody; Ly-75 antibody; DEC-205 antibody; CD antigen CD205 antibody
Raised in Rabbit
Species Reactivity Mouse
Immunogen Recombinant Mouse Lymphocyte antigen 75 protein (28-211AA)
Immunogen Species Mus musculus (Mouse)
Conjugate Non-conjugated

The Ly75 Antibody (Product code: CSB-PA013251HA01MO) is Non-conjugated. For Ly75 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA013251HB01MO Ly75 Antibody, HRP conjugated ELISA
FITC CSB-PA013251HC01MO Ly75 Antibody, FITC conjugated
Biotin CSB-PA013251HD01MO Ly75 Antibody, Biotin conjugated ELISA
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Tested Applications ELISA
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment. Causes reduced proliferation of B lymphocytes.
Gene References into Functions
  1. this study shows that CD205-TLR9-IL-12 axis contributes to CpG-induced oversensitive liver injury in Hepatitis B viral antigens transgenic mice by promoting the interaction of NKT cells with Kupffer cells PMID: 27041637
  2. DNA vaccines encoding DEC205-targeted antigens induce peripheral tolerance rather than immunity PMID: 25819746
  3. The DEC-205-mediated antigen targeting to steady-state dendritic cells induces deletion of diabetogenic CD8 T cells independently of PD-1 and PD-L1. PMID: 24021877
  4. Through analysis of both polyclonal and monoclonal transgenic TCR T-cell development in the context of CD205 deficiency, we demonstrate that CD205 does not play an overt role in T cell development or selection. PMID: 23300927
  5. Introduction of a labile dipeptide linker at the N terminus of a T-cell epitope improves proteasome-dependent class I MHC-restricted peptide cross-presentation when delivered by alphaDEC205 in vitro and in vivo. PMID: 23297227
  6. Data indicate that the interaction between the PE-Cy5.5 conjugates and the cells expressing mDEC205 appears distinctive, since none of the PE-Cy5.5 conjugates bind to the cells that express human DEC205 on surface. PMID: 22841832
  7. CD205+ conventional dendritic cells impacts the regulation of T-cell immunity and homeostasis in vivo PMID: 22736794
  8. Langerin-positive dendritic cells appear to be the predominant, though not exclusive, population responsible for in vivo transport of anti-DEC-205 antibodies from the skin to the draining lymph nodes in steady state and inflammation. PMID: 22291181
  9. For production of cytotoxic T cells, DEC-205 and Clec9A, but not Clec12A, are effective targets for antibody-mediated delivery of antigens for vaccination, although only in the presence of adjuvants. PMID: 21677141
  10. Comparable T helper 1 (Th1) and CD8 T-cell immunity by targeting HIV gag p24 to CD8 dendritic cells within antibodies to Langerin, DEC205, and Clec9A. PMID: 21262813
  11. show that Flt3L DC efficiently crosspresent HIV gag via the DEC-205 receptor, about 100 times more effective than non-targeted gag. PMID: 19830741
  12. Results suggest that DEC-205 provides an efficient receptor-based mechanism for dendritic cells to process proteins for MHC class I presentation in vivo, leading to tolerance in the steady state and immunity after dendritic cell maturation. PMID: 12486105
  13. This protein was detected in mouse Langerhans cells on epidermis separated by microwave irradiation. PMID: 12503727
  14. Dendritic cell targeting via the DEC205 receptor in the presence of anti-CD40 and poly(I:C) as maturation stimuli, induced strong human and mouse survivin-specific CD4+ T cell responses PMID: 17142738
  15. murine DEC-205 is a receptor for PLA of Yersinia pestis PMID: 18650418
  16. CD205 acts as a recognition receptor for dying cells, potentially providing an important pathway for the uptake of self-antigen in intrathymic and peripheral tolerance. PMID: 19135256

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Subcellular Location Membrane; Single-pass type I membrane protein.
Tissue Specificity Expressed in dendritic and thymic epithelial cells and lymph nodes.
Database Links

KEGG: mmu:17076

STRING: 10090.ENSMUSP00000028362

UniGene: Mm.2074

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