MAGEA6 Antibody

Datasheet

Code	CSB-PA013332ESR2HU
Size	US$166
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Image	Western blot All lanes: MAGEA6 antibody at 7μg/ml Lane 1: Rat brain tissue Lane 2: Rat gonad tissue Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 35 kDa Observed band size: 35 kDa Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA013332ESR2HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA013332ESR2HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) MAGEA6 Polyclonal antibody

Uniprot No.

P43360

Target Names

MAGEA6

Alternative Names

MAGEA6 antibody; MAGE6 antibody; Melanoma-associated antigen 6 antibody; Cancer/testis antigen 1.6 antibody; CT1.6 antibody; MAGE-6 antigen antibody; MAGE3B antigen antibody

Raised in

Rabbit

Species Reactivity

Human, Rat

Immunogen

Recombinant Human Melanoma-associated antigen 6 protein (75-314AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Activator of ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases that acts as a as repressor of autophagy. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines.

Gene References into Functions

MAGEA6 knockdown by targeted-shRNA induced AMPK stabilization and activation, which led to mTOR complex 1 (mTORC1) in-activation and RCC cell death/apoptosis. PMID: 29448247
MAGEA6 promotes glioma cell survival possibly via targeting AMPKalpha1. PMID: 29024810
MageA6 and MageA11 form a protein complex resulting in the stabilization of MageA11 and consequently the enhancement of androgen receptor activity. PMID: 28542476
To identify novel CTL epitopes from MAGE-A6 and MAGE-A12 antigens. PMID: 22707303
Disease-associated bias in T helper type 1 (Th1)/Th2 CD4(+) T cell responses against MAGE-6 in HLA-DRB10401(+) patients with renal cell carcinoma or melanoma. PMID: 12208877
MAGE-6 encodes HLA-DRbeta1*0401-presented epitopes recognized by CD4+ T cells from patients with melanoma or renal cell carcinoma PMID: 12631591

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Tissue Specificity

Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes.

Database Links

HGNC: 6804

OMIM: 300176

KEGG: hsa:4105

STRING: 9606.ENSP00000329199

UniGene: Hs.441113

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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