MAPK6 Antibody

1. Metformin sensitizes arsenic trioxide to suppress intrahepatic cholangiocarcinoma via the regulation of AMPK/p38 MAPK-ERK3/mTORC1 pathways. ERK3 is a newfound potential prognostic predictor and a tumor suppressor in ICC. PMID: 28241849
2. Study revealed a post-translational regulation of TDP2 activity and discovered a new role of ERK3 in increasing cancer cells' DNA damage response and chemoresistance to Top2 inhibitors. PMID: 26701725
3. MAPK6 could rescue the cell growth induced by miR499a and HBV PMID: 25340781
4. ERK3 regulates endothelial cell migration, proliferation and tube formation by upregulating SRC-3/SP-1-mediated VEGFR2 expression. PMID: 24585635
5. These findings further expand distinct roles of cyclin D3 and suggest the potential activity of ERK3 in cell proliferation. PMID: 16360641
6. Cdc14A forms a stable complex with atypical mitogen-activated protein kinase Erk3 in human cells independent of its intrinsic phosphatase activity but mediated by its regulatory C-terminal domain. PMID: 18235225
7. identify the Erk3 protein as a novel class I Pak substrate and further suggest a role for Pak kinase activity in atypical MAPK signaling. PMID: 21317288
8. A previously unknown role for ERK3 in promoting lung cancer cell invasiveness by phosphorylating SRC-3 and regulating SRC-3 proinvasive activity by site-specific phosphorylation. PMID: 22505454
9. ERK3 biological activity is regulated by its cellular abundance through the control of protein stability PMID: 12808096
10. Data show that extracellular signal-regulated kinase 3 (ERK3) is conjugated to ubiquitin via its free NH(2) terminus, and that N-terminal tags stabilize expression of p21 but not that of substrates ubiquitinated on internal lysine residues. PMID: 15226418
11. Extracellular signal-regulated kinase-3 (ERK3/MAPK6) is highly expressed in response to BRAF signaling. PMID: 16964379

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HGNC: 6879

OMIM: 602904

KEGG: hsa:5597

STRING: 9606.ENSP00000261845

UniGene: Hs.411847