MASTL Antibody

1. Using mathematical modelling, this paper confirms that deactivation of MASTL is essential for mitotic exit. PMID: 26872783
2. these results established that precise control of MASTL is essential to couple DNA damage to mitosis through the rate of mitotic entry and APC/C activation. PMID: 26923777
3. Thus, GWL is a human oncoprotein that promotes the hyperactivation of AKT via the degradation of its phosphatase, PHLPP, in human malignancies. PMID: 26613407
4. Thus, Fcp1 coordinates Cdk1 and Gwl inactivation to derepress PP2A-B55, generating a dephosphorylation switch that drives mitosis progression. PMID: 26653855
5. Boolean modeling identifies Greatwall/MASTL as an important regulator in the AURKA network of neuroblastoma. PMID: 26616283
6. Data show that siRNA knockdown of Forkhead box M1 (FOXM1) or microtubule-associated serine/threonine kinase-like (MASTL) induces radiosensitivity in non-small cell lung cancer (NSCLC). PMID: 25808837
7. Mastl upregulation is involved in cancer progression and tumor recurrence after initial cancer therapy PMID: 25373736
8. data demonstrate that GWL acts in a pathway with PP2A which is essential for prophase I exit and metaphase I microtubule assembly in mouse oocytes. PMID: 25472593
9. Taken together our results suggest a hierarchy of phosphatases coordinating Greatwall, Ensa/ARPP19 and Cdk substrate dephosphorylation during mitotic exit. PMID: 24391510
10. Studies indicate that mutations in three different genes within the THC2 locus have been associated with congenital thrombocytopenia, including a mutation in MASTL. PMID: 22102272
11. results identify Gwl as a member of the AGC family of kinases that appears to be regulated by unique mechanisms and that differs from the other members of this family PMID: 21444715
12. MASTL enhances cyclin B1-Cdk1-dependent mitotic phosphorylation events, directing mitotic entry, anaphase and cytokinesis in human cells. PMID: 20818157
13. A novel missense mutation in the human gene FLJ14813 is associated with autosomal dominant thrombocytopenia PMID: 12890928
14. A paper that narrows the identity of the gene for autosomal dominant thrombocytopenia (THC2) to FLJ14813. The mutation is present in all affected people across three generations while is absent in unaffected family members & 94 random blood donors. PMID: 12890928

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HGNC: 19042

OMIM: 608221

KEGG: hsa:84930

STRING: 9606.ENSP00000365107

UniGene: Hs.276905