MC1R Antibody

Datasheet
Code CSB-PA122172
Size US$299
Uniprot No. Q01726
Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA122172(MC1R Antibody) at dilution 1/100, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using CSB-PA122172(MC1R Antibody) at dilution 1/100, on the right is treated with synthetic peptide. (Original magnification: ×200)
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunogen Synthetic peptide of Human MC1R
Raised in Rabbit
Species Reactivity Human,Mouse
Tested Applications ELISA,IHC;ELISA:1:1000-1:5000,IHC:1:50-1:200
Relevance This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation.
Form Liquid
Conjugate Non-conjugated
Storage Buffer -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method Antigen affinity purification
Isotype IgG
Alias melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
Immunogen Species Homo sapiens (Human)
Target Names MC1R
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.
Involvement in disease Melanoma, cutaneous malignant 5 (CMM5)
Subcellular Location Cell membrane, Multi-pass membrane protein
Protein Families G-protein coupled receptor 1 family
Tissue Specificity Melanocytes and corticoadrenal tissue.
Database Links

HGNC: 6929

OMIM: 155555

KEGG: hsa:4157

STRING: 9606.ENSP00000451605

UniGene: Hs.513829

Pathway Melanogenesis

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