MCRS1 Antibody, Biotin conjugated

1. Study shows that MCRS1 binds to cytoplasmic dynein and contributes to the establishment of centriolar satellites and ciliogenesis. PMID: 27263857
2. MSP58 downregulation suppressed the proliferation and invasion of renal cell carcinoma cells. PMID: 28448870
3. MCRS1 is phosphorylated by the Aurora-A kinase in mitosis on Ser35/36. PMID: 27192185
4. RINT-1 interacts with MSP58 and UBF within nucleoli and plays a role in ribosomal gene transcription. PMID: 27530925
5. The immunoreactivity score (IRS) of MSP58 increased with tumor grade with grade IV gliomas exhibiting the highest expression and showed a highly significant positive correlation with the Ki-67 index (r = 0.65, P < 0.001). PMID: 26849376
6. Suggest that MSP58 plays an important role in tumorigenesis and progression and may help predict the prognosis of gastric cancer patients. PMID: 27468560
7. MCRS1 overexpression induced non-small cell lung cancer proliferation through the miR-155-Rb1 pathway and DNA copy-number amplification is one of the mechanisms underlying MCRS1 overexpression in non-small cell lung cancer. PMID: 26467212
8. MSP58 subnuclear localization is regulated by two nuclear import signals, and proper subcellular localization of MSP58 is critical for its role in transcriptional regulation. A molecular mechanism controls nuclear and nucleolar localization of MSP58. PMID: 25981436
9. BAP1 loss and MCRS1 down-regulation in renal cell carcinoma are associated with adverse clinicopathological features. PMID: 26300492
10. MiR-129* down-regulation induced MCRS1 overexpression. PMID: 25373388
11. High expression of MSP58 was also an independent unfavorable prognostic factor. PMID: 23996240
12. MSP58 could suppress the transcription of hTERT promoter. PMID: 24361335
13. MSP58 expression in hepatocellular carcinoma is closely related to the prognosis. PMID: 23519485
14. Our results demonstrated MSP58 might serve as a novel prognostic marker for colorectal cancer PMID: 22773039
15. MSP58 contributes to the tumorigenesis of neuroblastoma by promoting cell proliferation. PMID: 22975844
16. RACGAP1 and MCRS1 overexpression in nonsmall-cell lung cancer.RACGAP1 and MCRS1 may be cancer-related genes in NSCLC. PMID: 23225332
17. MSP58 depletion induced cell cycle arrest. PMID: 22994740
18. Interaction between microspherule protein Msp58 and ubiquitin E3 ligase EDD regulates cell cycle progression. PMID: 23069210
19. Our findings highlight new aspects of MSP58 in modulating cellular senescence and suggest that MSP58 has both oncogenic and tumor-suppressive properties. PMID: 22563078
20. MCRS2 plays a negative role in stress-induced ASK1 activation. PMID: 22609355
21. MCRS1 is a RanGTP-regulated factor essential for non-centrosomal microtubule assembly. PMID: 22081094
22. the sequence of MCRS2 and determines that the nuclear localization signal, which has the sequence KRKK, is situated between amino acids 66 and 69 PMID: 21533551
23. These data highlight the importance of MSP58 in glioma progression. PMID: 18798870
24. role in the modulation of Daxx-dependent transcriptional repression PMID: 11948183
25. Mi-2beta and RFP, known to be involved in transcriptional repression in the nucleus, co-localize with MCRS1 in the nucleolus and appear to activate the rRNA transcription. PMID: 16186106
26. A subset of the p78 proteins comprises a component of the centrosome; p78 is essential for cell viability. PMID: 16547491
27. Escorts fragile X mental retardation protein-containing silent ribonucleoparticles (mRNP)from the nucleus and nucleolus to the somato-dendritic compartment where it might participate in neuronal translation regulation. PMID: 16571602
28. DIPA can act as a repressor of gene transcription, an activity that appears to be enhanced by p78. PMID: 17014843
29. modulation of Ndrg2 level influences the cell cycle process together with MSP58 PMID: 17109818
30. MCRS2, a new Nrf1-interacting protein, has a repression effect on Nrf1-mediated transcriptional activation PMID: 19187526
31. Overexpression of MSP58 is associated with colorectal cancer. PMID: 19549253

Show More

Hide All

HGNC: 6960

OMIM: 609504

KEGG: hsa:10445

STRING: 9606.ENSP00000349640

UniGene: Hs.25313