MCRS1

MCRS1, also known as microglobulin 1, has alternative names such as P78, MCRS2, MSP58, INO80Q, and ICP22BP. MCRS1 is part of the Ino80 complex, MLL1 complex, and histone acetyltransferase complex, participating in the negative regulation of histone H4 acetylation, DNA metabolism processes, and the positive regulation of protein localization to nucleoli.
Abnormal expression of MCRS1 is associated with various diseases, particularly in the development and progression of tumors. MCRS1 is highly expressed in solid tumors such as lung cancer and pancreatic cancer, and it influences the sensitivity of tumor cells to immunotherapy by regulating the expression of MHC-I molecules, making it a new therapeutic target and predictive marker. Additionally, MCRS1 is involved in gene transcription regulation and cell transformation processes, playing a significant role in the occurrence and development of malignant tumors.