Name: MCRS1 Antibody
Brand: CUSABIO
SKU: CSB-PA013611LA01HU

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) MCRS1 Polyclonal antibody

Uniprot No.

Q96EZ8

Target Names

MCRS1

Alternative Names

58 kDa microspherule protein antibody; Cell cycle regulated factor (78 kDa) antibody; Cell cycle regulated factor p78 antibody; Cell cycle-regulated factor p78 antibody; ICP22BP antibody; INO80 complex subunit J antibody; MCRS 1 antibody; MCRS 2 antibody; MCRS1 antibody; MCRS1_HUMAN antibody; MCRS2 antibody; Microspherule protein 1 antibody; MSP 58 antibody; MSP58 antibody; p78 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Microspherule protein 1 protein (1-138AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The MCRS1 Antibody (Product code: CSB-PA013611LA01HU) is Non-conjugated. For MCRS1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA013611LB01HU	MCRS1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA013611LC01HU	MCRS1 Antibody, FITC conjugated
Biotin	CSB-PA013611LD01HU	MCRS1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Target Background

Function

Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity. Binds to G-quadruplex structures in mRNA. Binds to RNA homomer poly(G) and poly(U).

Gene References into Functions

Study shows that MCRS1 binds to cytoplasmic dynein and contributes to the establishment of centriolar satellites and ciliogenesis. PMID: 27263857
MSP58 downregulation suppressed the proliferation and invasion of renal cell carcinoma cells. PMID: 28448870
MCRS1 is phosphorylated by the Aurora-A kinase in mitosis on Ser35/36. PMID: 27192185
RINT-1 interacts with MSP58 and UBF within nucleoli and plays a role in ribosomal gene transcription. PMID: 27530925
The immunoreactivity score (IRS) of MSP58 increased with tumor grade with grade IV gliomas exhibiting the highest expression and showed a highly significant positive correlation with the Ki-67 index (r = 0.65, P < 0.001). PMID: 26849376
Suggest that MSP58 plays an important role in tumorigenesis and progression and may help predict the prognosis of gastric cancer patients. PMID: 27468560
MCRS1 overexpression induced non-small cell lung cancer proliferation through the miR-155-Rb1 pathway and DNA copy-number amplification is one of the mechanisms underlying MCRS1 overexpression in non-small cell lung cancer. PMID: 26467212
MSP58 subnuclear localization is regulated by two nuclear import signals, and proper subcellular localization of MSP58 is critical for its role in transcriptional regulation. A molecular mechanism controls nuclear and nucleolar localization of MSP58. PMID: 25981436
BAP1 loss and MCRS1 down-regulation in renal cell carcinoma are associated with adverse clinicopathological features. PMID: 26300492
MiR-129* down-regulation induced MCRS1 overexpression. PMID: 25373388
High expression of MSP58 was also an independent unfavorable prognostic factor. PMID: 23996240
MSP58 could suppress the transcription of hTERT promoter. PMID: 24361335
MSP58 expression in hepatocellular carcinoma is closely related to the prognosis. PMID: 23519485
Our results demonstrated MSP58 might serve as a novel prognostic marker for colorectal cancer PMID: 22773039
MSP58 contributes to the tumorigenesis of neuroblastoma by promoting cell proliferation. PMID: 22975844
RACGAP1 and MCRS1 overexpression in nonsmall-cell lung cancer.RACGAP1 and MCRS1 may be cancer-related genes in NSCLC. PMID: 23225332
MSP58 depletion induced cell cycle arrest. PMID: 22994740
Interaction between microspherule protein Msp58 and ubiquitin E3 ligase EDD regulates cell cycle progression. PMID: 23069210
Our findings highlight new aspects of MSP58 in modulating cellular senescence and suggest that MSP58 has both oncogenic and tumor-suppressive properties. PMID: 22563078
MCRS2 plays a negative role in stress-induced ASK1 activation. PMID: 22609355
MCRS1 is a RanGTP-regulated factor essential for non-centrosomal microtubule assembly. PMID: 22081094
the sequence of MCRS2 and determines that the nuclear localization signal, which has the sequence KRKK, is situated between amino acids 66 and 69 PMID: 21533551
These data highlight the importance of MSP58 in glioma progression. PMID: 18798870
role in the modulation of Daxx-dependent transcriptional repression PMID: 11948183
Mi-2beta and RFP, known to be involved in transcriptional repression in the nucleus, co-localize with MCRS1 in the nucleolus and appear to activate the rRNA transcription. PMID: 16186106
A subset of the p78 proteins comprises a component of the centrosome; p78 is essential for cell viability. PMID: 16547491
Escorts fragile X mental retardation protein-containing silent ribonucleoparticles (mRNP)from the nucleus and nucleolus to the somato-dendritic compartment where it might participate in neuronal translation regulation. PMID: 16571602
DIPA can act as a repressor of gene transcription, an activity that appears to be enhanced by p78. PMID: 17014843
modulation of Ndrg2 level influences the cell cycle process together with MSP58 PMID: 17109818
MCRS2, a new Nrf1-interacting protein, has a repression effect on Nrf1-mediated transcriptional activation PMID: 19187526
Overexpression of MSP58 is associated with colorectal cancer. PMID: 19549253

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Subcellular Location

Nucleus. Nucleus, nucleolus. Cytoplasm.

Tissue Specificity

Detected in testis, and at lower levels in spleen, thymus, prostate, uterus, small intestine, colon and leukocytes.

Database Links

HGNC: 6960

OMIM: 609504

KEGG: hsa:10445

STRING: 9606.ENSP00000349640

UniGene: Hs.25313

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Code	CSB-PA013611LA01HU
Size	US$166
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Image	Western blot All lanes: MCRS1 antibody at 8μg/ml Lane 1: Jurkat whole cell lysate Lane 2: Hela whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 52, 54, 51, 32 kDa Observed band size: 52 kDa Immunohistochemistry of paraffin-embedded human glioma using CSB-PA013611LA01HU at dilution of 1:100
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MCRS1 Antibody

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Target Background