Code | CSB-PA013627LA01HU |
Size | US$166 |
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The MDM4 Antibody (Product code: CSB-PA013627LA01HU) is Non-conjugated. For MDM4 Antibody with conjugates, please check the following table.
Application | Recommended Dilution |
---|---|
WB | 1:500-1:5000 |
To prepare the MDM4 antibody, a rabbit is immunized with recombinant human MDM4 protein (208-306aa). Next, the resulting polyclonal antibody mixture is isolated from the rabbit's serum and purified using protein G affinity chromatography, achieving a purity level of 95%. The purified MDM4 polyclonal antibody undergoes ELISA and WB assays to test its specificity for human and mouse MDM4 proteins.
The MDM4 protein regulates the activity of p53 and prevents its tumor-suppressive functions. MDM4 also has p53-independent functions, such as regulating cell proliferation and differentiation. Aberrant expression or activity of MDM4 has been implicated in the development and progression of several types of cancer, including breast, lung, and ovarian cancer.
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