ME1 Antibody, HRP conjugated

Code CSB-PA013632LB01HU
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) ME1 Polyclonal antibody
Uniprot No. P48163
Target Names ME1
Alternative Names Cytosolic malic enzyme 1 antibody; HUMNDME antibody; Malate dehydrogenase antibody; Malic enzyme 1 antibody; Malic enzyme 1; NADP(+) dependent; cytosolic antibody; Malic enzyme 1; soluble antibody; Malic enzyme; cytoplasmic antibody; MAOX_HUMAN antibody; ME1 antibody; MES antibody; NADP dependent malic enzyme antibody; NADP ME antibody; NADP-dependent malic enzyme antibody; NADP-ME antibody; Pyruvic malic carboxylase antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human NADP-dependent malic enzyme protein (161-519AA)
Immunogen Species Homo sapiens (Human)
Conjugate HRP
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Tested Applications ELISA
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Gene References into Functions
  1. Bioinformatics analysis identified that miR612 targeted ME1, which expression was high and inversely associated with miR612 expression in bladder cancer tissues. PMID: 29620192
  2. Findings indicate that malic enzyme 1 (ME1) is a valid target for molecular therapy in oral squamous cell carcinomas (OSCCs). PMID: 29601126
  3. these findings uncover a direct cross-talk mechanism between ME1 and PPP, may reveal an alternative model for signaling transduction via protein conformational simulation, and pave the way for better understanding how metabolic pathways are coordinated in cancer. PMID: 28848047
  4. ME1/ME2 expression phenotype may have a potential to be a valuable marker for sebaceous differentiation in sebaceous lesions. PMID: 26381116
  5. ME1 expression was found to be mutant-KRAS-associated in NSCLC cancer cell lines. Patients with elevated ME1 had worse outcomes after radiotherapy. Transamination generating cytosolic NADPH via ME1 may contribute to radioresistance. PMID: 26173780
  6. ME1 overexpression associates with unfavorable prognoses in patients with HCC, suggesting that ME1 is a poor prognostic predictor of hepatocellular carcinoma. PMID: 25753478
  7. essential role for ME1 in the production of cytosolic NADPH and maintenance of migratory and invasive abilities of nasopharyngeal carcinoma cells PMID: 23114090
  8. the differential protein stability between dimer and tetramer interface interactions of human c-NADP-ME PMID: 23284632
  9. p53 represses the expression of the tricarboxylic-acid-cycle-associated malic enzymes ME1 and ME2 in human and mouse cells PMID: 23334421
  10. cytosolic malic enzyme 1 gene polymorphism is associated with the degree of suppression of parathyroid hormone after long-term calcium supplementation; the effect is probably mediated through an increase in intestinal calcium absorption PMID: 22456781
  11. ME1 is a functional target gene of the BACH1 transcription factor according to ChIP-seq and knockdown analysis in HEK 293 cells. PMID: 21555518
  12. that the single mutation of Gln362 to Lys in human m-NAD-ME changes it to an NADP+-dependent enzyme, which is characteristic because it is non-allosteric, non-cooperative, and NADP+-specific PMID: 16757477
  13. although ME1 overexpression augments anaplerosis and glucose stimulated insulin secretion in INS-1 832/13 cells, it is not likely involved in methyl succinate and glucose stimulated insulin secretion in pancreatic islets PMID: 19293334
  14. human c-NADP-ME exists mainly as a tetramer, whereas human m-NAD(P)-ME exists as a mixture of dimers and tetramers PMID: 19416979
  15. A series of R98/D102 mutants examined the possible interactions between Arg98 and Asp102 using double-mutant cycle analysis. Kinetic analysis revealed that the catalytic efficiency of was severely affected by mutating both Arg98 and Asp102 residues. PMID: 19464998

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Subcellular Location Cytoplasm.
Protein Families Malic enzymes family
Tissue Specificity Expressed in all tissues tested including liver, placenta and white adipose tissue.
Database Links

HGNC: 6983

OMIM: 154250

KEGG: hsa:4199

STRING: 9606.ENSP00000358719

UniGene: Hs.21160

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