MECR Antibody

Datasheet

Code	CSB-PA887132LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: Rat heart tissue All lanes: MECR antibody at 3.3μg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 41, 33 kDa Observed band size: 41 kDa Immunohistochemistry analysis of human liver cancer using CSB-PA887132LA01HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) MECR Polyclonal antibody

Uniprot No.

Q9BV79

Target Names

MECR

Alternative Names

AI195831 antibody; CGI 63 antibody; FASN2B antibody; Homolog of yeast 2 enoyl thioester reductase antibody; HsNrbf-1 antibody; HsNrbf1 antibody; mecr antibody; MECR_HUMAN antibody; Mitochondrial 2 enoyl thioester reductase antibody; mitochondrial antibody; NRBF 1 antibody; NRBF-1 antibody; NRBF1 antibody; Nuclear receptor binding factor 1 antibody; Nuclear receptor-binding factor 1 antibody; OTTMUSP00000009996 antibody; RP23-13A13.1 antibody; Trans 2 enoyl CoA reductase; mitochondrial antibody; Trans-2-enoyl-CoA reductase antibody

Raised in

Rabbit

Species Reactivity

Human, Rat

Immunogen

Recombinant Human Trans-2-enoyl-CoA reductase, mitochondrial protein (211-373AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The MECR Antibody (Product code: CSB-PA887132LA01HU) is Non-conjugated. For MECR Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA887132LB01HU	MECR Antibody, HRP conjugated	ELISA
FITC	CSB-PA887132LC01HU	MECR Antibody, FITC conjugated
Biotin	CSB-PA887132LD01HU	MECR Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Displays a preference for medium-chain over short- and long-chain substrates. May provide the octanoyl chain used for lipoic acid biosynthesis, regulating protein lipoylation and mitochondrial respiratory activity particularly in Purkinje cells.

Gene References into Functions

MECR is involved in mitochondrial fatty acid synthesis, and overexpression of this gene increases peroxisome proliferator-activated receptor alpha (PPARalpha) activity. PMID: 27845578
results suggest that mutations in MECR cause a distinct human disorder of the mitochondrial fatty acid synthesis pathway; the observation of decreased lipoylation raises the possibility of a potential therapeutic strategy PMID: 27817865
overexpression of MECR, the last step in the mitochondrial fatty acid synthesis (mtFASII) pathway, causes modulation of gene expression through the PPAR pathway. PMID: 24161390
The crystal structure of this dimeric enzyme (at 2.4 A resolution) suggests that the binding site for the recognition helix of the acyl carrier protein is in a groove between the two adjacent monomers. PMID: 18479707

Involvement in disease

Dystonia, childhood-onset, with optic atrophy and basal ganglia abnormalities (DYTOABG)

Subcellular Location

[Isoform 1]: Mitochondrion.; [Isoform 2]: Cytoplasm. Nucleus.

Protein Families

Zinc-containing alcohol dehydrogenase family, Quinone oxidoreductase subfamily

Tissue Specificity

Highly expressed in skeletal and heart muscle. Expressed at lower level in placenta, liver, kidney and pancreas. Weakly or not expressed in lung.

Database Links

HGNC: 19691

OMIM: 608205

KEGG: hsa:51102

STRING: 9606.ENSP00000263702

UniGene: Hs.183646

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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