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MED27 Antibody, HRP conjugated

Datasheet
Code CSB-PA764716LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) MED27 Polyclonal antibody
Uniprot No.
Q6P2C8
Target Names
MED27
Alternative Names
Cofactor required for Sp1 transcriptional activation subunit 8 (34kD) antibody; Cofactor required for Sp1 transcriptional activation subunit 8 34kDa antibody; Cofactor required for Sp1 transcriptional activation subunit 8 antibody; CRAP 34 antibody; CRAP34 antibody; CRSP 34 antibody; CRSP 8 antibody; CRSP complex subunit 8 antibody; CRSP34 antibody; CRSP8 antibody; MED 27 antibody; Med27 antibody; MED27_HUMAN antibody; Mediator complex subunit 27 antibody; Mediator of RNA polymerase II transcription subunit 27 antibody; MGC11274 antibody; P37 TRAP/SMCC/PC2 subunit antibody; Transcriptional coactivator CRSP34 antibody; TRAP 37 antibody; TRAP37 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Mediator of RNA polymerase II transcription subunit 27 protein (39-108AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
ELISA Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Gene References into Functions
  1. The findings of the present study may aid in the clarification of the function of miR18a, particularly as regards its role in the regulation of Osteosarcoma (OS)cell apoptosis, and indicate that MED27 may be a potential novel therapeutic target in the treatment of OS. PMID: 29693135
  2. MED27 promotes melanoma growth by targeting AKT/MAPK and NF-kappaB/iNOS signaling pathways. PMID: 26797421
Subcellular Location
Nucleus.
Protein Families
Mediator complex subunit 27 family
Database Links

HGNC: 2377

OMIM: 605044

KEGG: hsa:9442

STRING: 9606.ENSP00000292035

UniGene: Hs.374262

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