MEIS2 Antibody

1. High expression of MEIS2 impairs repressive DNA binding of AML1-ETO, inducing increased expression of genes such as the druggable proto-oncogene YES1. PMID: 27346355
2. we have identified a novel nonsense MEIS2 mutation in a female patient with cleft palate, cardiac septal defect, severe ID, developmental delay and feeding difficulty with gastro-esophageal reflux. Our findings strongly suggest neurocristopathy be included in the clinical features associated with MEIS2 alterations. PMID: 27225850
3. Meis2 as the target of miR-134 in the regulation of cardiomyocyte progenitor cell proliferation. PMID: 26512644
4. This is the first report showing a de novo small intragenic mutation in MEIS2 and further confirms the important role of this gene in normal development. PMID: 25712757
5. Our results show that MEIS2 is a gene needed for palate closure. In syndromic cases of cleft palate, MEIS2 should be considered among the candidate genes, for example, in cases without 22q11.2 deletions. PMID: 24678003
6. FOXM1 is a direct target gene of MEIS2 and is required for MEIS2 to upregulate mitotic genes. PMID: 25210800
7. Klf4 recruits a complex of Meis and Pbx proteins to DNA, resulting in Meis2 transcriptional activation domain-dependent activation of a subset of Klf4 target genes. PMID: 21746878
8. The Single Nucleotide Polymorphism in Meis homeobox 2 (MEIS2) mediated the effects of risperidone on hip circumference (q=0.004). PMID: 20195266
9. Transgenic mice lacking microRNAs miR-9-2 and miR-9-3 exhibit multiple defects of telencephalic structures which may be brought about by dysregulation of Foxg1, Nr2e1, Gsh2, and Meis2 expression. PMID: 21368052
10. Data demonstrate by in situ hybridization and immunohistochemistry that the two homeobox genes Pax6 and MEIS2 are expressed during early fetal brain development in humans. PMID: 20523026
11. This work suggests that the transcriptional activity of all members of the Meis/Prep Hth protein family is subject to autoinhibition by their Hth domains, and that the Meis3.2 splice variant encodes a protein that bypasses this autoinhibitory effect. PMID: 20553494
12. Clinical trial and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 20195266
13. Analysis of an Affymetrix data set in the public domain showed high expression of MEIS1 in human endometrium PMID: 18408019

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HGNC: 7001

OMIM: 600987

KEGG: hsa:4212

STRING: 9606.ENSP00000453793

UniGene: Hs.510989