MEMO1 Antibody

Datasheet

Code	CSB-PA896500ESR1HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human thyroid tissue using CSB-PA896500ESR1HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA896500ESR1HU at dilution of 1:100
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) MEMO1 Polyclonal antibody

Uniprot No.

Q9Y316

Target Names

MEMO1

Alternative Names

C21orf19-like protein antibody; C2orf4 antibody; CGI 27 antibody; DKFZp434I0135 antibody; FLJ25031 antibody; HCV NS5A-transactivated protein 7 antibody; Hepatitis C virus NS5A-transactivated protein 7 antibody; Mediator of cell motility 1 antibody; Mediator of ErbB2-driven cell motility 1 antibody; MEMO antibody; Memo-1 antibody; memo1 antibody; MEMO1_HUMAN antibody; NS5ATP7 antibody; Protein MEMO1 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Protein MEMO1 protein (1-297AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Is required for breast carcinoma cell migration.

Gene References into Functions

Study identify Memo as an important key mediator between the heregulin and estrogen signaling pathways, which affects both breast cancer cell migration and proliferation. PMID: 27472465
HRG/HER2/HER3 signaling promotes AhR-mediated Memo-1 expression and migration in colorectal cancer PMID: 27941874
Biochemical assays revealed that Memo is a copper-dependent redox enzyme that promoted a more oxidized intracellular milieu and stimulated the production of reactive oxygen species (ROS) in cellular structures involved in migration. PMID: 24917593
Mediator of ERBB2-driven cell motility (MEMO) promotes extranuclear estrogen receptor signaling involving the growth factor receptors IGF1R and ERBB2. PMID: 23861392
MEMO1 is involved in breast carcinogenesis via regulating insulin-like growth factor-I receptor-dependent signaling events. PMID: 22824790
data suggest that Memo controls cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton [Memo] PMID: 15156151
2.1A crystal structure and homology to class III nonheme iron-dependent dioxygenases PMID: 18045866
Memo-RhoA-mDia1 signaling coordinates the organization of the lamellipodial actin network, adhesion site formation, and microtubule outgrowth within the cell leading edge to sustain cell motility. PMID: 18955552
Memo was detected in complexes with cofilin, ErbB2 and PLCgamma1. PMID: 19223396

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Protein Families

MEMO1 family

Database Links

HGNC: 14014

OMIM: 611786

KEGG: hsa:51072

STRING: 9606.ENSP00000295065

UniGene: Hs.444969

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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