MGAT1 Antibody

1. In this study we showed that the activation of Wnt/beta-catenin pathway culminates in the upregulation of MGAT1 enzyme both at transcriptional and post-transcriptional levels. We also showed that overexpression of the beta-catenin gene (CTNNB1) increased the promoter activity of MGAT1. PMID: 29310626
2. The presence of the rs4285184 polymorphism of the MGAT1 gene increased the risk for developing body fat associated with obesity in the Mexican population. PMID: 27871764
3. MGAT1 is downregulated in peripheral blood mononuclear cells of galactosaemia patients. PMID: 26733289
4. The authors show here that the luminal domain of GnT1IP-L contains its MGAT1 inhibitory activity. PMID: 26371870
5. UDP-galactose (SLC35A2) and UDP-N-acetylglucosamine (SLC35A3) Transporters Form Glycosylation-related Complexes with Mannoside Acetylglucosaminyltransferases (Mgats). PMID: 25944901
6. The IL2RA and IL7RA variants had univariate association in MS and T1D, whereas the MGAT1 and CTLA-4 variants associated with only MS or T1D, respectively. PMID: 24572742
7. analysis of suppression of cancer progression by MGAT1 shRNA knockdown PMID: 22957033
8. Genetic variants downstream MGAT1 seem to influence susceptibility to obesity. Moreover, these genetic variants affect the levels of serum unsaturated fatty acids and Delta desaturase indices, variables previously shown to correlate with obesity. PMID: 21304485
9. Activity of HuGnTI in plants is limited by a combination of reduced protein stability, alternative protein targeting and possibly to some extend to lower enzymatic performance of the catalytic domain in the plant biochemical environment. PMID: 19826906
10. The analysis enabled us to identify a new candidate gene, MGAT1, associated with weight in women. PMID: 19851299
11. Findings indicated that cysteine 121 has a structural role in maintaining active site geometry of hGnT1, rather than a catalytic role, and illustrates for the first time the potential utility of E. coli as an expression system for hGnT1. PMID: 17716624

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HGNC: 7044

OMIM: 160995

KEGG: hsa:4245

STRING: 9606.ENSP00000311888

UniGene: Hs.519818