MGAT1

MGAT1, also known as alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase, catalyzes the first committed step in the synthesis of complex and hybrid N-glycans. It plays a crucial role in protein glycosylation, an important post - translational modification. This enzyme is involved in the N - glycan synthesis pathway, which is essential for protein folding, stability, and cell - cell recognition.
Dysfunction of MGAT1 has been linked to congenital disorders of glycosylation. In drug development, targeting MGAT1 could potentially lead to new therapies for diseases related to abnormal glycosylation. Some research is exploring inhibitors of MGAT1 to understand its full therapeutic potential in treating associated pathologies.