MGAT4B Antibody

Datasheet

Code	CSB-PA890781LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: SH-SY5Y whole cell lysate, Jurkat whole cell lysate All lanes: MGAT4B antibody at 3µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 64, 65 kDa Observed band size: 64 kDa IHC image of CSB-PA890781LA01HU diluted at 1:300 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) MGAT4B Polyclonal antibody

Uniprot No.

Q9UQ53

Target Names

MGAT4B

Alternative Names

3-D-mannoside beta-1 antibody; 3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B antibody; 4-N-acetylglucosaminyltransferase IVb antibody; Alpha 1 3 mannosyl glycoprotein beta 1 4 N acetylglucosaminyltransferase antibody; Alpha-1 antibody; Aminyltransferase antibody; GlcNAc T IVb antibody; GlcNAc-T IVb antibody; GNT IV antibody; GNT IVB antibody; GnT-IVb antibody; GNTIV antibody; GNTIVB antibody; Mannosyl (alpha 1 3) glycoprotein beta 1 4 N acetylglucosaminyltransferase isozyme B antibody; MGAT 4B antibody; mgat4b antibody; MGT4B_HUMAN antibody; N acetylglucosaminyltransferase IVb antibody; N glycosyl oligosaccharide glycoprotein antibody; N glycosyl oligosaccharide glycoprotein N acetylglucosaminyltransferase IVb antibody; N-acetylglucosaminyltransferase IVb antibody; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVb antibody; UDP N acetylglucosamine alpha 1 3 D mannoside beta 1 4 N acetylglucosaminyltransferase IV antibody; UDP N acetylglucosamine alpha 1 3 D mannoside beta 1 4 N acetylglucosaminyltransferase IVb antibody; UDP-N-acetylglucosamine: alpha-1 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B protein (380-522AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The MGAT4B Antibody (Product code: CSB-PA890781LA01HU) is Non-conjugated. For MGAT4B Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA890781LB01HU	MGAT4B Antibody, HRP conjugated	ELISA
FITC	CSB-PA890781LC01HU	MGAT4B Antibody, FITC conjugated
Biotin	CSB-PA890781LD01HU	MGAT4B Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:200-1:500

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains. Has lower affinities for donors or acceptors than MGAT4A, suggesting that, under physiological conditions, it is not the main contributor in N-glycan biosynthesis.

Gene References into Functions

UDP-galactose (SLC35A2) and UDP-N-acetylglucosamine (SLC35A3) Transporters Form Glycosylation-related Complexes with Mannoside Acetylglucosaminyltransferases (Mgats). PMID: 25944901
analysis of expression of N-acetylglucosaminyltransferase-IVa and IVb (GnT-IVa and b) in pancreatic cancer PMID: 16434023
GnT-IVa is more active than GnT-IVb under physiological conditions and it primarily contributes to the biosynthesis of N-glycans. PMID: 17006639
We investigated mRNA levels of glycosyltransferases, namely, N-acetylglucosaminyltransferase a (GnT)-IVb, and found that (GnT)-IVb expression was increased in HLE-cells Epirubicin resistant. PMID: 17488527

Subcellular Location

Golgi apparatus membrane; Single-pass type II membrane protein.

Protein Families

Glycosyltransferase 54 family

Tissue Specificity

Widely expressed. Strongly overexpressed in pancreatic cancer.

Database Links

HGNC: 7048

OMIM: 604561

KEGG: hsa:11282

STRING: 9606.ENSP00000338487

UniGene: Hs.567419

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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