MLK4 Antibody

Code CSB-PA259340
Size US$297
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  • Western blot analysis of extracts from HT-29 cells, using MAP3KL4 antibody.
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) MAP3K21 Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
dJ862P8.3 antibody; KIAA1804 antibody; M3KL4_HUMAN antibody; Mitogen activated protein kinase kinase kinase antibody; Mitogen-activated protein kinase kinase kinase MLK4 antibody; Mixed lineage kinase 4 antibody; MLK 4 antibody; Mlk4 antibody; RP5 862P8.2 antibody
Raised in
Species Reactivity
Synthesized peptide derived from internal of Human MAP3KL4.
Immunogen Species
Homo sapiens (Human)
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
It differs from different batches. Please contact us to confirm it.
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:3000
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways.
Gene References into Functions
  1. These results suggest that in the early response to stressful stimuli, MLK4beta-MLK3 binding is important for regulating MLK3 activity and MAPK signalling, and after prolonged periods of stress exposure, MLK4beta and MLK3 proteins decline via CHIP-dependent degradation. PMID: 28757353
  2. results uncover MLK4 as an upstream regulator of NF-kappaB signaling and a potential molecular target for the MES subtype of glioblastomas PMID: 26859459
  3. In establishing the role of MLK4 in intracellular signaling, we show it directly phosphorylates MEK1 (MAP2K1) and that MEK/ERK (MAPK1) signaling is impaired in MLK4 knockout cells PMID: 23319808
  4. MLK4 is a negative regulator of TLR4 signaling. PMID: 21602844
Protein Families
Protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase kinase subfamily
Database Links

HGNC: 29798

OMIM: 614793

KEGG: hsa:84451

STRING: 9606.ENSP00000355583

UniGene: Hs.547779

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