MS4A3 Antibody, HRP conjugated

Code CSB-PA856947LB01HU
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) MS4A3 Polyclonal antibody
Uniprot No. Q96HJ5
Target Names MS4A3
Alternative Names MS4A3; CD20L; HTM4; Membrane-spanning 4-domains subfamily A member 3; CD20 antigen-like protein; Hematopoietic-specific transmembrane protein 4; HTm4
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Membrane-spanning 4-domains subfamily A member 3 protein (1-49AA)
Immunogen Species Homo sapiens (Human)
Conjugate HRP
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Tested Applications ELISA
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Hematopoietic modulator for the G1-S cell cycle transition. Modulates the level of phosphorylation of cyclin-dependent kinase 2 (CDK2) through its direct binding to cyclin-dependent kinase inhibitor 3 (CDKN3/KAP).
Gene References into Functions
  1. These results suggest that cell surface expression of MS4A3 is useful to distinguish granulocyte/macrophage lineage-committed progenitors from other lineage-related ones in early human hematopoiesis. In conclusion, MS4A3 is useful to monitor early stage of myeloid differentiation in human hematopoiesis. PMID: 29274779
  2. a 7-gene signature was identified which correctly predicted the primary prefibrotic myelofibrosis group with a sensitivity of 100% and a specificity of 89%. The 7 genes included MPO, CEACAM8, CRISP3, MS4A3, CEACAM6, HEMGN, and MMP8 PMID: 27579896
  3. Our data reveal MS4A3 as a novel direct target of EVI1 in human myeloid cells, and show that its repression plays a role in EVI1 mediated tumor aggressiveness. PMID: 25886616
  4. The C-terminal domain is important for the function of HTm4 in cell cycle regulation. PMID: 15830103
  5. High HTm4 is associated with neoplasms. PMID: 19818099

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Subcellular Location Endomembrane system; Multi-pass membrane protein. Cytoplasm, perinuclear region. Note=Located in the perinuclear area.
Protein Families MS4A family
Tissue Specificity Expressed specifically in hematopoietic cells and tissues.
Database Links

HGNC: 7317

OMIM: 606498

KEGG: hsa:932

STRING: 9606.ENSP00000278865

UniGene: Hs.99960

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