MTERF1 Antibody

Datasheet

Code	CSB-PA811872LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: HL60 whole cell lysate, K562 whole cell lysate All lanes: MTERF1 antibody at 2.6μg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 46 kDa Observed band size: 46 kDa
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) MTERF1 Polyclonal antibody

Uniprot No.

Q99551

Target Names

MTERF1

Alternative Names

mitochondrial antibody; Mitochondrial transcription termination factor 1 antibody; mTERF antibody; MTERF_HUMAN antibody; Transcription termination factor antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Transcription termination factor 1, mitochondrial protein (63-232AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The MTERF1 Antibody (Product code: CSB-PA811872LA01HU) is Non-conjugated. For MTERF1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA811872LB01HU	MTERF1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA811872LC01HU	MTERF1 Antibody, FITC conjugated
Biotin	CSB-PA811872LD01HU	MTERF1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Transcription termination factor. Binds to a 28 bp region within the tRNA(Leu(uur)) gene at a position immediately adjacent to and downstream of the 16S rRNA gene; this region comprises a tridecamer sequence critical for directing accurate termination. Binds DNA along the major grove and promotes DNA bending and partial unwinding. Promotes base flipping. Transcription termination activity appears to be polarized with highest specificity for transcripts initiated on the light strand.

Gene References into Functions

MTERF1 has the ability to accommodate alternate active conformations. PMID: 26523681
It has been demonstrated that MTERF1 arrests mitochondrial DNA (mtDNA) replication with distinct polarity whereby MTERF1 acts as a directional contra-helicase, blocking mtDNA unwinding by the mitochondrial helicase TWINKLE. PMID: 27112570
Studies indicate that the structure of the mitochondrial transcription termination factor (MTERF1) provides insight into the mechanism of binding, recognition of the termination sequence and the conformational changes involved in mediating termination. PMID: 21326908
Single nucleotide polymorphism in MTERF gene is associated with epithelial ovarian cancer. PMID: 21447778
data suggested that hMTERF4 is an essential factor for cell proliferation, which is probably modulated by mitochondrial transcription to promote cell proliferation PMID: 21450691
Data show that mTERF protein levels materially affect the amount of readthrough transcription on the antisense strand of mtDNA, whilst the effects on sense-strand transcripts are complex, and suggest the influence of compensatory mechanisms. PMID: 20846394
Presented are the crystal structures of human mitochondrial regulator MTERF, a transcription termination factor also implicated in replication pausing, in complex with double-stranded DNA oligonucleotides containing the tRNA(Leu)(UUR) gene sequence. PMID: 20543826
The structure indicates that upon sequence recognition MTERF1 unwinds the DNA molecule, promoting eversion of three nucleotides. PMID: 20550934
mTERF mRNA levels were higher in elite athletes compared with moderately active subjects PMID: 19681768
mTERF exists in mitochondria in two forms, an active monomer and an inactive large size complex PMID: 14744862
monomeric human mTERF is fully active in its non-phosphorylated form and that the protein does not require additional cellular factors to terminate mitochondrial transcription in vitro PMID: 15899902
analysis of DNA light-strand preferential recognition of human mitochondria transcription termination factor mTERF PMID: 16336784
Results indicate a role for mTERF in mtDNA replication, in addition to its role in transcription. PMID: 17884915

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Subcellular Location

Mitochondrion.

Protein Families

MTERF family

Database Links

HGNC: 21463

OMIM: 602318

KEGG: hsa:7978

STRING: 9606.ENSP00000248643

UniGene: Hs.532216

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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