MTIF3 Antibody

Code CSB-PA008192
Size US$100
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  • Western Blot analysis of HuvEC cells using IF3 Polyclonal Antibody
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Product Details

Uniprot No.
Target Names
MTIF3
Alternative Names
DC38 antibody; IF 3 antibody; IF 3Mt antibody; IF-3(Mt) antibody; IF-3Mt antibody; IF3 antibody; IF3(mt) antibody; IF3M_HUMAN antibody; IF3mt antibody; mitochondrial antibody; Mt antibody; MTIF3 antibody; Translation initiation factor IF 3; mitochondrial precursor antibody; Translation initiation factor IF-3 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthesized peptide derived from the Internal region of Human IF3.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, IHC, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:40000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
IF-3 binds to the 28S ribosomal subunit and shifts the equilibrum between 55S ribosomes and their 39S and 28S subunits in favor of the free subunits, thus enhancing the availability of 28S subunits on which protein synthesis initiation begins.
Gene References into Functions
  1. genetic association studies in cohorts of prediabetic patients at multiple sites: Data suggest that an SNP in MTIF3 (rs1885988) is associated with greater weight loss following lifestyle intervention in overweight/obese subjects with prediabetes. PMID: 26253612
  2. single nucleotide polymorphisms rs4771122 of MTIF3 was the variant most significantly associated with long-term weight loss after surgery. PMID: 26337695
  3. Changes in function or expression of MTIF3 indicates mitochondrial dysfunction and contributes to the risk of Parkinson's disease. PMID: 20887776
  4. the c.798C>T polymorphism of the MTIF3 gene showed allelic association with Parkinson's disease PMID: 17267121
Subcellular Location
Mitochondrion.
Protein Families
IF-3 family
Database Links

HGNC: 29788

KEGG: hsa:219402

STRING: 9606.ENSP00000370508

UniGene: Hs.534582

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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