MTUS1 Antibody

1. MTUS1 is not only involved in the formation and progression of human cancers but also involved in the complex pathological conditions such as cardiac hypertrophy, atherosclerosis, and SLE-like lymphoproliferative diseases. Several molecular mechanisms such as proliferation, differentiation, DNA repair, inflammation, vascular remodeling and senescence appear to be tightly regulated by the MTUS1-encoded proteins. PMID: 28499941
2. findings have provided the first clues regarding the roles of miR-19a/b, which appear to function as oncomirs in lung cancer by downregulating MTUS1. PMID: 28364280
3. angiotensin II type 2 receptor-interacting protein 3a presents potential in suppressing the proliferation and aggressiveness of ovarian carcinoma cells through the high mobility group AT-hook 2-mediated extracellular signal-regulated kinase/epithelial-to-mesenchymal transition signal pathway. PMID: 28651497
4. Our findings showed that MTUS1 regulates the p38 MAPK-mediated cytokine production in ECs. MTUS1 gene probably plays a protective role against pro-inflammatory response of ECs. PMID: 27789289
5. MTUS1 targeting miRNAs may play key roles in the development of CRC by downregulating tumor suppressor MTUS1. PMID: 26643896
6. Study reports differential expression of MTUS1 and its regulatory miRNAs in breast cancer and fibroadenoma tissues; among MTUS1 targeting miRNAs, miR-183-5p was overexpressed in breast cancer and down-regulated in fibroadenoma tissues; expression levels of MTUS1 and miR-183-5p correlated with clinical parameters. In particular, MTUS1 was found to be diminished and miR-183-5p was elevated with advancing stage. PMID: 27155522
7. We propose a novel mechanism by which ATIP3-EB1 interaction indirectly reduces the kinetics of EB1 exchange on its recognition site, thereby accounting for negative regulation of microtubule dynamic instability PMID: 26498358
8. Deregulated microRNA (miRNA) expression has been shown to be involved in the pathogenesis of several types of cancers including colorectal cancer (CRC). MTUS1 targeting miRNAs may play key roles in the development of CRC by downregulating tumor suppressor MTUS1. PMID: 26643896
9. Our studies confirm that MTUS1 plays an important role in the progression of salivary adenoid cystic carcinoma , and may serve as a biomarker or therapeutic target for patients with salivary adenoid cystic carcinoma PMID: 25885343
10. Data identifies MTUS1 as a tumour suppressor gene in cultured bladder cancer cells and in advanced bladder tumours. PMID: 24650297
11. The present data suggested MTUS1 as a potential tumor suppressor in gastric cancer and might lead to a better understanding of gastric carcinogenesis. PMID: 24299308
12. analysis of a functional ATIP3 domain that associates with microtubules and recapitulates the effects of ATIP3 on microtubule dynamics, cell proliferation, and migration in breast cancer PMID: 23396587
13. MTUS1 plays major roles in the progression of oral tongue squamous cell carcinoma. PMID: 22153618
14. ATIP3 is a novel microtubule-associated protein isoform of MTUS1, with a role in invasiveness and progression of breast neoplasms. PMID: 19794912
15. Results in human prostate cancer cell lines demonstrate the presence of ATIP in both cell lines examined. PMID: 20687230
16. MTUS1 could be involved in the loss of proliferative control in human colon cancer PMID: 19956880
17. ATIP3 is a novel microtubule-associated protein related to MTUS1, with a role in invasiveness and progression of breast neoplasms PMID: 19794912
18. identified a tumor suppressor gene named MTSG1 at chromosome 8p21.3-22, encoding a mitochondrial protein, controlling cellular proliferation PMID: 12692079
19. Results identify ATIP1 (angiotensin II AT2 receptor-interacting protein) as a novel early component of growth inhibitory signaling cascade PMID: 15123706
20. Nucleotide variations result in amino-acid substitution or deletion of conserved structural motifs and also exonic splicing enhancer motifs and physiological splice sites, suggesting deleterious effects on ATIP function and/or expression. [REVIEW] PMID: 16650523
21. MTUS1 encodes a family of proteins(ATIP1, ATIP3 and ATIP4), with potential important biological roles in tumor suppression and/or brain function. PMID: 16887298
22. There is an association of the deletion variant of MTUS1 with a decreased risk for both familial and high-risk familial BC supporting its role in human cancer. PMID: 17301065
23. two transcriptional start sites in the ATIP1 promoter were identified; PARP-1 activates the ATIP1 gene PMID: 19344625

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HGNC: 29789

OMIM: 114550

KEGG: hsa:57509

STRING: 9606.ENSP00000262102

UniGene: Hs.7946