MYO3B Antibody

Code CSB-PA848841LA01HU
See More Details Free Antibody trial simple
Size US$299
Uniprot No. Q8WXR4
  • IHC image of CSB-PA848841LA01HU diluted at 1:400 and staining in paraffin-embedded human melanoma performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunogen Recombinant Human Myosin-IIIb protein (1110-1276AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA, IHC; Recommended dilution: IHC:1:200-1:500
Relevance Probable actin-based motor with a protein kinase activity.
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Myosin-IIIb (EC, MYO3B
Immunogen Species Human
Research Area Signal Transduction
Target Names MYO3B
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Probable actin-based motor with a protein kinase activity. Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern. Involved in the elongation of actin in stereocilia tips by transporting the actin regulatory factor ESPN to the plus ends of actin filaments.
Subcellular Location Cytoplasm, cytoskeleton, Cell projection, stereocilium
Protein Families TRAFAC class myosin-kinesin ATPase superfamily, Myosin family; Protein kinase superfamily, STE Ser/Thr protein kinase family
Tissue Specificity Expressed in retina, kidney and testis.
Database Links

HGNC: 15576

OMIM: 610040

KEGG: hsa:140469

STRING: 9606.ENSP00000386213

UniGene: Hs.671900

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