MYOM1 Antibody

1. Crystal structure of the obscurin(-like-1):myomesin complex reveals a trans-complementation mechanism whereby an incomplete immunoglobulin-like domain assimilates an isoform-specific myomesin interdomain sequence. PMID: 27989621
2. individual subfragments of titin and myomesin composed of Fn type III and Ig-like domains can activate expression of two IGF-1 splice forms in cultured myoblasts PMID: 25152160
3. myomesin could act as a highly elastic ribbon to maintain the overall structural organization of the sarcomeric M-band. PMID: 22347812
4. Our results suggest that the downregulation of MBNL proteins should lead to the abnormal splicing of MYOM1 exon 17a in DM1 muscle. PMID: 21794030
5. EH-myomesin levels were up-regulated at least 10 times in dilated cardiomyopathy patients compared to controls. PMID: 21069531
6. This missense mutation caused significant changes of biochemical and biophysical properties of myomesin fragments indicating a role in the pathogenesis of hypertrophic cardiomyopathy . PMID: 21256114
7. Results identify muscle-type creatine kinase as a binding partner of a central portion of myomesin and the closely related M-protein. PMID: 12972258
8. visco-elastic properties of myomesin might be crucial for the stability of the sarcomere PMID: 15890201

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HGNC: 7613

OMIM: 603508

KEGG: hsa:8736

STRING: 9606.ENSP00000348821

UniGene: Hs.464469