Mut Antibody, HRP conjugated

Datasheet

Code	CSB-PA015243YB01MO
Size	US$166
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Target Background

Product Details

Full Product Name

Rabbit anti-Mus musculus (Mouse) Mut Polyclonal antibody

Uniprot No.

P16332

Target Names

Mut

Alternative Names

Mmut antibody; Mut antibody; Methylmalonyl-CoA mutase antibody; mitochondrial antibody; MCM antibody; EC 5.4.99.2 antibody; Methylmalonyl-CoA isomerase antibody

Raised in

Rabbit

Species Reactivity

Mouse

Immunogen

Recombinant Mouse Methylmalonyl-CoA mutase, mitochondrial protein (31-748AA)

Immunogen Species

Mus musculus (Mouse)

Conjugate

HRP

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Catalyzes the reversible isomerization of methylmalonyl-CoA (MMCoA) (generated from branched-chain amino acid metabolism and degradation of dietary odd chain fatty acids and cholesterol) to succinyl-CoA (3-carboxypropionyl-CoA), a key intermediate of the tricarboxylic acid cycle.

Gene References into Functions

On a high protein diet, mutant mice display disease exacerbation, including elevated blood ammonia, and catastrophic weight loss, which, in Mut(ki/ki) mice, is rescued by hydroxocobalamin treatment. This study expands knowledge of MMAuria, introduces the discovery of new biomarkers, and constitutes the first in vivo proof of principle of cobalamin treatment in mut-type MMAuria. PMID: 27519416
The mouse methylmalonic aciduria- related genes, Mmaa, Mmab, and Mut may have specialized functions depending on the tissue or cell type. PMID: 23022071
Includes the study of an upstream ORF in this gene, and shows that it functions to reduce protein levels by ~61%. PMID: 19372376
methylmalonyl-CoA mutase has a role in methylmalonic aciduria and early neonatal lethality PMID: 14555645
Mitochondrial dysfunction in Mut is reported. PMID: 19088183

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Subcellular Location

Mitochondrion matrix. Mitochondrion. Cytoplasm.

Protein Families

Methylmalonyl-CoA mutase family

Database Links

KEGG: mmu:17850

STRING: 10090.ENSMUSP00000130941

UniGene: Mm.259884

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