Mut Antibody, Biotin conjugated

Code CSB-PA015243YD01MO
Size US$166
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Product Details

Full Product Name
Rabbit anti-Mus musculus (Mouse) Mut Polyclonal antibody
Uniprot No.
Target Names
Mut
Alternative Names
Mmut antibody; Mut antibody; Methylmalonyl-CoA mutase antibody; mitochondrial antibody; MCM antibody; EC 5.4.99.2 antibody; Methylmalonyl-CoA isomerase antibody
Raised in
Rabbit
Species Reactivity
Mouse
Immunogen
Recombinant Mouse Methylmalonyl-CoA mutase, mitochondrial protein (31-748AA)
Immunogen Species
Mus musculus (Mouse)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function
Catalyzes the reversible isomerization of methylmalonyl-CoA (MMCoA) (generated from branched-chain amino acid metabolism and degradation of dietary odd chain fatty acids and cholesterol) to succinyl-CoA (3-carboxypropionyl-CoA), a key intermediate of the tricarboxylic acid cycle.
Gene References into Functions
  1. On a high protein diet, mutant mice display disease exacerbation, including elevated blood ammonia, and catastrophic weight loss, which, in Mut(ki/ki) mice, is rescued by hydroxocobalamin treatment. This study expands knowledge of MMAuria, introduces the discovery of new biomarkers, and constitutes the first in vivo proof of principle of cobalamin treatment in mut-type MMAuria. PMID: 27519416
  2. The mouse methylmalonic aciduria- related genes, Mmaa, Mmab, and Mut may have specialized functions depending on the tissue or cell type. PMID: 23022071
  3. Includes the study of an upstream ORF in this gene, and shows that it functions to reduce protein levels by ~61%. PMID: 19372376
  4. methylmalonyl-CoA mutase has a role in methylmalonic aciduria and early neonatal lethality PMID: 14555645
  5. Mitochondrial dysfunction in Mut is reported. PMID: 19088183

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Subcellular Location
Mitochondrion matrix. Mitochondrion. Cytoplasm.
Protein Families
Methylmalonyl-CoA mutase family
Database Links
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