NAA50 Antibody

Code CSB-PA880928ESR2HU
Size US$166
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Image
  • Western blot
    All lanes: NAA50 antibody at 5ug/ml
    Lane 1: K562 whole cell lysate
    Lane 2: Jurkat whole cell lysate
    Lane 3: Hela whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 20, 10 kDa
    Observed band size: 20 kDa

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) NAA50 Polyclonal antibody
Uniprot No.
Target Names
NAA50
Alternative Names
ody; FLJ13194 antibody; hNAT5 antibody; hSAN antibody; Mak3 homolog (S. cerevisiae) antibody; Mak3 homolog antibody; N-acetyltransferase 13 (GCN5-related) antibody; N-acetyltransferase 13 antibody; N-acetyltransferase 5 antibody; N-acetyltransferase san homolog antibody; N-alpha-acetyltransferase 50 antibody; N-alpha-acetyltransferase 50; NatE catalytic subunit antibody; Naa50 antibody; NAA50_HUMAN antibody; NAT 5 antibody; NAT13 antibody; NAT5 antibody; NatE catalytic subunit antibody; San antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human N-alpha-acetyltransferase 50 protein (1-169AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
N-alpha-acetyltransferase that acetylates the N-terminus of proteins that retain their initiating methionine. Has a broad substrate specificity: able to acetylate the initiator methionine of most peptides, except for those with a proline in second position. Also displays N-epsilon-acetyltransferase activity by mediating acetylation of the side chain of specific lysines on proteins. Autoacetylates in vivo. The relevance of N-epsilon-acetyltransferase activity is however unclear: able to acetylate H4 in vitro, but this result has not been confirmed in vivo. Component of N-alpha-acetyltransferase complexes containing NAA10 and NAA15, which has N-alpha-acetyltransferase activity. Does not influence the acetyltransferase activity of NAA10. However, it negatively regulates the N-alpha-acetyltransferase activity of the N-terminal acetyltransferase A complex (also called the NatA complex). The multiprotein complexes probably constitute the major contributor for N-terminal acetylation at the ribosome exit tunnel, with NAA10 acetylating all amino termini that are devoid of methionine and NAA50 acetylating other peptides. Required for sister chromatid cohesion during mitosis by promoting binding of CDCA5/sororin to cohesin: may act by counteracting the function of NAA10.
Gene References into Functions
  1. Because Naa10 is reported to acetylate all amino termini that are devoid of methionine and Naa50 acetylates all other peptides that are followed by methionine PMID: 27484799
  2. co-depletion of NatA, a heterodimeric NAT complex that physically interacts with Naa50, rescues the sister-chromatid cohesion defects and the resulting mitotic arrest caused by Naa50 depletion, indicating that NatA and Naa50 play antagonistic roles in cohesion. PMID: 27422821
  3. The study quantitatively compared the Nt-acetylomes of wild-type yeast S. cerevisiae expressing the endogenous yeast Naa50 (yNaa50), the congenic strain lacking yNaa50, and an otherwise identical strain expressing human Naa50 (hNaa50). PMID: 25886145
  4. Development of the first N-terminal acetyltransferase (NAT) inhibitors, including a specific Naa50 inhibitor. PMID: 23557624
  5. The first description of the human homologue of Nat5p/San, hNAT5, the third component of the human NatA N-alpha-acetyltransferase complex PMID: 16507339
  6. Nat5 displays both protein N alpha- and N epsilon-acetyltransferase activity. PMID: 19744929
  7. Human protein N-terminal acetyltransferase hNaa50p (hNAT5/hSAN) follows ordered sequential catalytic mechanism: combined kinetic and NMR study. PMID: 22311970
  8. Naa50p can accommodate only an alpha-amino substrate and not a side chain lysine substrate that is acetylated by lysine acetyltransferase enzymes such as Gcn5. PMID: 21900231
  9. May be specifically required for the maintenance of centromeric cohesion in mitosis. PMID: 17502424

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Subcellular Location
Cytoplasm. Nucleus.
Protein Families
Acetyltransferase family, GNAT subfamily
Database Links

HGNC: 29533

OMIM: 610834

KEGG: hsa:80218

STRING: 9606.ENSP00000240922

UniGene: Hs.372378

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