NAA60 Antibody

Datasheet

Code	CSB-PA875691LA01HU
Size	US$166
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Image	IHC image of CSB-PA875691LA01HU diluted at 1:900 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) NAA60 Polyclonal antibody

Uniprot No.

Q9H7X0

Target Names

NAA60

Alternative Names

FLJ11693 antibody; FLJ14154 antibody; HAT4 antibody; Histone acetyltransferase type B protein 4 antibody; N acetyltransferase 15 (GCN5 related, putative) antibody; N alpha acetyltransferase 60 antibody; N(alpha) acetyltransferase 60, NatF catalytic subunit antibody; N-acetyltransferase 15 antibody; N-alpha-acetyltransferase 60 antibody; naa60 antibody; NAA60_HUMAN antibody; NAT15 antibody; NatF catalytic subunit antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human N-alpha-acetyltransferase 60 protein (1-94AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The NAA60 Antibody (Product code: CSB-PA875691LA01HU) is Non-conjugated. For NAA60 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA875691LB01HU	NAA60 Antibody, HRP conjugated	ELISA
FITC	CSB-PA875691LC01HU	NAA60 Antibody, FITC conjugated
Biotin	CSB-PA875691LD01HU	NAA60 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:500-1:1000

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function

N-alpha-acetyltransferase that specifically mediates the acetylation of N-terminal residues of the transmembrane proteins, with a strong preference for N-termini facing the cytosol. Displays N-terminal acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met. Required for normal chromosomal segregation during anaphase. May also show histone acetyltransferase activity; such results are however unclear in vivo and would require additional experimental evidences.

Gene References into Functions

Results from a study on gene expression variability markers in early-stage human embryos shows that NAA60 (NAT15) is a putative expression variability marker for the 3-day, 8-cell embryo stage. PMID: 26288249
The hNaa60 protein contains an amphipathic helix following its GNAT domain that may contribute to Golgi localization of hNaa60, and the beta7-beta8 hairpin adopted different conformations in the hNaa60(1-242) and hNaa60(1-199) crystal structures. PMID: 27550639
analysis of the mode of cytosolic Naa60 anchoring to the Golgi apparatus, most likely occurring post-translationally and specifically facilitating post-translational N-terminal acetylation of many transmembrane proteins PMID: 28196861
Knockdown of the N-terminal acetyltransferase Naa60 compromises Golgi ribbon integrity. PMID: 26164078
The first crystal structure of the N-terminal acetyltransferase Naa60 reveals two elongated loops important for substrate-specific binding not found in other NAT structures. PMID: 27320834
Naa60 is necessary for maintenance of the Golgi ribbon through its Nt-acetylation of substrate protein(s) that is/are involved in Golgi ribbon structural and/or functional organization. PMID: 25732826
Naa60 is an N-terminal acetyltransferase defined as NatF. Human and Drosophila melanogaster Naa60 acetylate Met-Lys- and other Met-starting N-termini. In Drosophila cells, NAA60 knockdown induced chromosomal segregation defects. PMID: 21750686
HAT4 is an important player in the organization and function of the genome and may contribute to the diversity and complexity of higher eukaryotic organisms [HAT4] PMID: 21981917

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Subcellular Location

Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.

Protein Families

Acetyltransferase family, NAA60 subfamily

Database Links

HGNC: 25875

OMIM: 614246

KEGG: hsa:79903

STRING: 9606.ENSP00000385903

UniGene: Hs.513296

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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