NCK1 Antibody

Datasheet
Code CSB-PA015530DSR2HU
Size US$167Purchase it in Cusabio online store
(only available for customers from the US)
Uniprot No. P16333
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Image
  • Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA015530DSR2HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA015530DSR2HU at dilution of 1:100

Immunogen Recombinant Human Cytoplasmic protein NCK1 protein (58-377AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA, IHC; Recommended dilution: IHC:1:20-1:200
Relevance Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors.
Form Liquid
Conjugate Non-conjugated
Storage Buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification Method Antigen Affinity purified
Isotype IgG
Clonality Polyclonal
Alias Cytoplasmic protein NCK1 (NCK adaptor protein 1) (Nck-1) (SH2/SH3 adaptor protein NCK-alpha), NCK1, NCK
Immunogen Species Human
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Research Area Signal Transduction
Target Names NCK1
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Function Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors.
Subcellular Location Cytoplasm, Endoplasmic reticulum, Nucleus
Database Links

HGNC: 7664

OMIM: 600508

KEGG: hsa:4690

STRING: 9606.ENSP00000288986

UniGene: Hs.126889

Pathway ErbB signaling pathway
T cell receptor signaling pathway

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