NCOA7 Antibody

Code CSB-PA127723
Size US$297
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  • Western blot analysis of extracts from LOVO cells, 3T3 cells and RAW264.7 cells, using NCOA7 antibody.
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) NCOA7 Polyclonal antibody
Uniprot No.
Target Names
NCOA7
Alternative Names
NCOA7 antibody; ERAP140 antibody; ESNA1 antibody; Nbla00052 antibody; Nbla10993 antibody; Nuclear receptor coactivator 7 antibody; 140 kDa estrogen receptor-associated protein antibody; Estrogen nuclear receptor coactivator 1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthesized peptide derived from internal of Human NCOA7.
Immunogen Species
Homo sapiens (Human)
Clonality
Polyclonal
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications
ELISA,WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:3000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Enhances the transcriptional activities of several nuclear receptors. Involved in the coactivation of different nuclear receptors, such as ESR1, THRB, PPARG and RARA.
Gene References into Functions
  1. this study reveals NCOA7 as a potential biomarker in oral squamous cell carcinoma arising from oral submucous fibrosis PMID: 27509054
  2. These observations provide consistent evidence that genetic variants at the NCOA7 locus may confer a reduced risk of breast cancer. PMID: 21610108
  3. ERAP140 may represent a distinct class of nuclear receptor coactivators. ERAP140 is recruited by estrogen-bound ER alpha to the promoter region of endogenous ER alpha target genes in a cyclic pattern similar to that of other coactivators. PMID: 11971969
  4. NCOA7 encodes the nuclear counterpart of the mitochondrial OXR1 protein and in mammalian cells it may reduce the oxidative by-products of estrogen metabolite-mediated DNA damage. PMID: 17391516
  5. present findings indicate that ERAP140/Nbla10993 plays an important role in the regulation of ATRA-mediated neuronal differentiation, and is a novel member of prognostic indicators for neuroblastoma. PMID: 18497940

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Subcellular Location
Nucleus.
Protein Families
OXR1 family
Tissue Specificity
Highly expressed in brain. Weakly expressed in mammary gland, ovary, uterus, prostate, stomach, bladder, spinal cord and pancreas. Expressed in cancer cell line.
Database Links

HGNC: 21081

OMIM: 609752

KEGG: hsa:135112

STRING: 9606.ENSP00000357341

UniGene: Hs.171426

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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