NCR1 Antibody

Code CSB-PA015549LA01HU
Size US$299Purchase it in Cusabio online store
(only available for customers from the US)
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  • Immunohistochemistry of paraffin-embedded human lymph node tissue using CSB-PA015549LA01HU at dilution of 1:100

  • Immunofluorescent analysis of A549 cells using CSB-PA015549LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) NCR1 Polyclonal antibody
Uniprot No. O76036
Target Names NCR1
Alternative Names Activating NK receptor NK p46 antibody; CD335 antibody; FLJ99094 antibody; hNKp46 antibody; Ly94 antibody; Lymphocyte antigen 94 antibody; Lymphocyte antigen 94 homolog (activating NK receptor, NK p46) antibody; Lymphocyte antigen 94 homolog antibody; Natural cytotoxicity triggering receptor 1 antibody; Natural killer cell p46-related protein antibody; NCR1 antibody; NCT1 antibody; NCTR1_HUMAN antibody; NK cell activating receptor antibody; NK cell-activating receptor antibody; NK-p46 antibody; NKp46 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Natural cytotoxicity triggering receptor 1 protein (121-230AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
IF 1:50-1:200
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Citations

MicroRNA-1 Negatively Regulates Peripheral NK Cell Function via Tumor Necrosis Factor-Like Weak Inducer of Apoptosis (TWEAK) Signaling Pathways …. Qi X,Frontiers in Immunology,2020

Applications: Flow Cytometric Analysis
Sample type: NK cell
Review: Multiple labeling of surface receptors was performed on goat NK cells against the molecules: CD16, CD14, NKp46, CD3, and SLAM. Representative FACS plots showing freshly sorted goat CD16+CD14− cell labeled with anti-NKp46 mAb, anti-CD3 mAb, or isotype control mAb.
PMID: 32038620

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Target Data

Function Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.
Gene References into Functions
  1. this paper shows that the decreased expression of activating receptor NKp46 on peripheral blood NK cells is positively associated with gastric cancer progression PMID: 30255106
  2. HIF-1alpha inhibits NCR1/NKp46 pathway through up-regulating miR-224, which affects the killing capability of NK cells on prostate cancer, thus inducing immune escape of tumor cells. PMID: 29885835
  3. The authors demonstrated that mutant NKp46 W32R is aberrantly glycosylated, accumulates in the endoplasmic reticulum, and is unstable on the cell surface. PMID: 28134248
  4. Low NKp46 expression on on NK cells is associated with Nasopharyngeal Carcinoma. PMID: 29580037
  5. Signaling via the natural killer cell receptor NKp46 (human) and Ncr1 (mouse) induced interferon-gamma (IFN-gamma) secretion from intratumoral natural killer cells. PMID: 29329948
  6. findings show HIV reservoir size is dependent on the presence of a defined NK cell population with a specific transcriptional signature: high NCR (NKp46 and NKp30) and IFN-gamma inducibility upon NCR and cytokine receptor engagement PMID: 28956765
  7. NKp46 cleavage by Cathepsin G severely impairs NKp46-mediated responses of Natural killer cells. PMID: 27587403
  8. The NKp46 and NKp46-ligand interaction contributes to NK cell activation. PMID: 28328926
  9. this study shows that the NKp46-activating receptor recognizes an unknown ligand expressed by human metapneumovirus-infected cells PMID: 28191644
  10. Intrahepatic NKp46 NK cells exhibited anti-HCV activity via cell-to-cell contact. The variation of the NKp46 proportion in individuals could be attributed to the diversity of HCV resistance observed in these individuals. PMID: 26714120
  11. Taken together, these results demonstrate that endogenous levels of IFN-alpha secreted by plasmacytoid dendritic cells induce natural killer cells to lyse HIV-1-infected autologous CD4+ primary T cells via the engagement of NKp46 and NKG2D. PMID: 26372382
  12. NKp46 was thus involved in the production of serine proteases and interleukin-22 in human mast cells. PMID: 25940096
  13. Age and CMV serostatus influence the expression of NKp30, NKp46 and DNAM-1 activating receptors on resting and IL-2 activated natural killer cells. PMID: 25991472
  14. Ncr1-Noe proteins accumulate in the endoplasmic reticulum, and that the expression of Ncr1-Noe proteins, but not WT Ncr1, leads to increased Helios expression PMID: 26371250
  15. Data show that regulatory dendritic cells (regDC) restrain IFN-gamma secretion by NK cells through secretion of interleukin-10 (IL-10), engagement of MHC class I-specific inhibitory receptors, and the activating receptor NKp46. PMID: 26232426
  16. Expression of NKp46/NCR1 in NK cells was significantly higher in untreated severe aplastic anemia patients than those in remission SAA and controls. This may be the reason for the hyperfunction of the immune system in SAA patients. PMID: 26554241
  17. Downregulated NKG2D, NKp46, and DNAM-1 receptors associated with impaired NK cell effector function are important biomarkers of advanced disease with a poor prognosis in melanoma patients. PMID: 24769842
  18. Women, w/ or w/o endometriosis, having larger populations of cytotoxic CD16(+) uterine NK cells and/or higher populations of NKp46(+)CD56(+) cells may be at greater risk of infertility resulting from inflammatory environment during implantation or later PMID: 24807109
  19. IL-15+IL-12 has an immunomodulatory effect on NK cell subsets from HIV-infected individuals viz down-regulation of iNKRs, elevation of activatory receptors NKp46 and NKG2D, and induction of coreceptor NKp80. PMID: 22715368
  20. NKp46 marks out pathologically activated natural killer cells, which may result from a loss of homeostatic control of activating receptor expression in hepatitis C virus. PMID: 23665989
  21. NKp46 is expressed on CD4 lymphocytes in mycosis fungoides and Sezary syndrome. PMID: 23900021
  22. Cytokine stimulation combined with natural killer cell receptor engagement are required for human natural killer cell functional diversity. PMID: 23490421
  23. involved in cytokine production of CD56+ NK cells in the uterine endometrium PMID: 23311919
  24. PLS3, Twist, KIR3DL2 and NKp46 gene expression can model efficient molecular Sezary syndrome diagnosis. PMID: 23429988
  25. NKp46 expression of hepatitis C virus replication controls the modulation of liver fibrosis. PMID: 22532190
  26. Race and gender related variation found in NKp46 receptor expression with differential anti-hepatitis C virus immunity. PMID: 22505144
  27. expressed in all investigated cases of transformed mycosis fungoides PMID: 22621189
  28. We suggest that NKp46 dimerization contributes to NKp46-mediated lysis by NK cells. PMID: 22615207
  29. NKp46 levels remain stable on the natural killer cells that persist at one week post-liver transplant in pediatric patients. PMID: 22360401
  30. important role in inhibition of liver fibrosis PMID: 22198715
  31. This study demonistrated that NCR1 expression on astrocytes in MS tissue. PMID: 22212381
  32. Role of runt-related transcription factor 3 (RUNX3) in transcription regulation of natural cytotoxicity receptor 1 (NCR1/NKp46), an activating natural killer (NK) cell receptor. PMID: 22253448
  33. findings show that NK cells can significantly accelerate neutrophil apoptosis, and that this process is dependent on cell-cell contact and mediated by the activating NK cell receptor NKp46 and the Fas pathway PMID: 22231698
  34. decreased expression is associated with altered NK-cell function in pediatric transplant patients with PTLD PMID: 22105417
  35. we investigate whether NKp46 is involved in the killing of human beta cells PMID: 21849674
  36. NKp46 identifies a functionally distinct NKT subset in that appears to be directly susceptible to leukemic transformation when IL-15 is overexpressed. PMID: 21364281
  37. Data show that an increase in 2B4-expressing NK cells and a decrease in NKp46(+) NK cells occurred following intramuscular influenza vaccination. PMID: 21214542
  38. peripheral blood malignant CD4(+) T lymphocytes from patients with Sezary syndrome, an aggressive form of cutaneous T-cell lymphoma, express NKp46 at their cell surface PMID: 21191411
  39. NKp46 interacts with heparin and heparan sulfate, highly sulfated glycans, and multimeric alpha2,3-NeuAc-containing N-glycan; these glycans interact mainly with basic amino acids in NKp46. PMID: 21329668
  40. Data show that only NKp46 appeared involved in the NK response. PMID: 21030563
  41. NKp46 is essential for the development of type 1 diabetes PMID: 20023661
  42. The NKp46 receptor participates in NK cell-mediated lysis of cells infected with the intracellular pathogen Mycobacterium tuberculosis, an activity that is reduced in tuberculosis patients compared with findings in healthy donors. PMID: 11907104
  43. crystal structure of the human natural killer (NK) cell activating receptor NKp46 PMID: 12960161
  44. NKp46 interacts with both viral hemagglutinins and the unknown tumor ligands via different mechanisms. PMID: 14504081
  45. CD59 is physically associated with NKp46 and NKp30 and activate human nk cell-mediated cytotoxicity. PMID: 14635045
  46. natural cytotoxicity receptor (NCR) and NK receptor member D of the lectin-like receptor family (NKG2D) were the key NK activating receptors for bone marrow-derived myeloma cell recognition PMID: 15328155
  47. NKp46 is not only a triggering molecule essential for antitumor activity but is also a surface receptor involved in natural killer cell suicide. PMID: 15728472
  48. Results examine residues in NKp46 that may be involved in heparan sulfate binding on tumor cells. PMID: 16262248
  49. defect in cytotoxic effector function is associated with a reduced surface expression of activating NK receptors (NKp30, NKp46, and NKG2D) on CD56(dim) NK cells compared with uninfected newborns. PMID: 16690951
  50. The natural cytotoxicity receptor NKp46 was required for the killing of all myeloma cell lines analyzed. PMID: 17875681

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Subcellular Location Cell membrane, Single-pass type I membrane protein
Protein Families Natural cytotoxicity receptor (NCR) family
Tissue Specificity Selectively expressed by both resting and activated NK cells.
Database Links

HGNC: 6731

OMIM: 604530

KEGG: hsa:9437

STRING: 9606.ENSP00000291890

UniGene: Hs.97084

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