NDN Antibody

1. the single-nucleotide polymorphism rs850807, which is putatively functional and linked with MAGEL2 and NDN Genetic variation in rs850807 was strongly and exclusively associated with the ideas of reference subscale of the schizophrenia spectrum, which is best typified as paranoia PMID: 29343559
2. this study shows that hypermethylation of NDN promotes cell proliferation by activating the Wnt signaling pathway in colorectal cancer PMID: 28521288
3. One candidate variant was located in an alpha helix of Necdin (NDN), phased to the paternally inherited allele. NDN is maternally imprinted within the 15q11.2 Prader-Willi Syndrome (PWS) region PMID: 28213671
4. NDN is an imprinted tumor suppressor gene which affects cancer cell motility, invasion and growth and that its loss of function in ovarian cancer can be caused by both genetic and epigenetic mechanisms. PMID: 26689988
5. Germline single nucleotide polymorphism in necdin gene is associated with breast cancer. PMID: 26384308
6. NDN and CD1A are novel prognostic methylation markers in patients with head and neck squamous carcinomas PMID: 26518708
7. Necdin expression declined during replicative aging of IMR90 primary human fibroblasts or after induction of premature senescence.Showed that in normal human cells, Necdin expression mimicked the effect of p53 inactivation by increasing radioresistance. PMID: 22691188
8. Hypermethylation and mutation of necdin is associated with neoplasms. PMID: 23549060
9. necdin exerts its pro-survival activity by counteracting the action of the pro-apoptotic protein Cell Cycle Apoptosis Regulatory Protein (CCAR1/CARP1) PMID: 22905258
10. necdin has multiple roles within protein complexes in different subcellular compartments, and indicate that it can utilize multiple karyopherin-dependent pathways to modulate its localization. PMID: 22442722
11. In pre-adipocytes, necdin over-expression inhibits adipogenesis, while reducing necdin levels enhances adipogenic differentiation in tissue culture cell PMID: 22305984
12. Necdin, a negative growth regulator,identified as a novel STAT3 target gene, whose expression is down-regulated at the mRNA and protein levels when STAT3 is constitutively active. PMID: 22046235
13. Necdin is implicated through the TNF-receptor 1 pathway in the developmental death of motoneuron PMID: 21912643
14. rare variant of necdin (p.V318A) was described in a family with Kallmann syndrome Familial segregation and in vitro analysis suggested that this non-synonymous variant did not have a direct causative role in hypogonadism phenotype. PMID: 21543378
15. Data suggest that the effects of necdin deletion on the developing nervous system may depend on the relative expression of p75NTR and TrkA in the cells of particular regions of the nervous system. PMID: 21150695
16. Necdin is a key protein regulating polarization of the cytoskeleton and myosin activation during development. PMID: 20665884
17. The necdin gene is imprinted, with preferential expression from the paternal allele in human and mouse. PMID: 9302265
18. the constitutively up-regulated expression of pre-IL-1 alpha in the nuclei of systemic sclerosis (SSc) fibroblasts up-regulates proliferation and matrix production of SSC fibroblasts through binding necdin PMID: 12913118
19. Tissue-specific gene expression regulation and imprinted epigenetic modifications of the human NDN gene. PMID: 15247330
20. Necdin can be a novel negative regulator of HIF-1alpha stability via the direct interaction. PMID: 15978586
21. Lack of Necdin expression induces perinatal serotonergic alterations that affect the maturation and function of the respiratory network, inducing breathing deficits in mice and probably in Prader-Willi patients. PMID: 18272695
22. Data suggest that Nogo-A is a novel necdin binding protein and inhibits necdin-accelerated neuronal neurite outgrowth by sequestering necdin in the cytoplasm. PMID: 19386232
23. regulates neuronal development. (review) PMID: 19517793
24. Confirmation of NDN as a tumor suppressor may have implications for monitoring of PWS patients and could present a novel cancer therapeutic target PMID: 19626646

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HGNC: 7675

OMIM: 176270

KEGG: hsa:4692

STRING: 9606.ENSP00000332643

UniGene: Hs.50130