NDUFS8 Antibody, Biotin conjugated

Datasheet

Code	CSB-PA015667LD01HU
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) NDUFS8 Polyclonal antibody

Uniprot No.

O00217

Target Names

NDUFS8

Alternative Names

CI 23kD antibody; CI-23kD antibody; Complex I 23kD antibody; Complex I-23kD antibody; EC 1.6.5.3 antibody; EC 1.6.99.3 antibody; Human mitochondrial NADH dehydrogenase ubiquinone Fe S protein 8 antibody; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8; mitochondrial antibody; NADH ubiquinone oxidoreductase 23 kDa subunit antibody; NADH-ubiquinone oxidoreductase 23 kDa subunit antibody; NDUFS8 antibody; NDUS8_HUMAN antibody; TYKY antibody; TYKY subunit antibody; Ubiquinoneiron sulfur protein 8; mitochondrial precursor antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial protein (35-210AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Biotin

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.

Gene References into Functions

Results show that NDUFS8 protein and mRNA levels are up-regulated in lung neoplasm and correlate with poor overall survival. PMID: 27516145
2 new mutations (P85L upstream from the 2 cysteine motifs that coordinate the two [4Fe-4S] clusters which generate the complex I N2 clusters, & R138H between them)suggest that this subunit is essential for either the assembly or stability of complex I. PMID: 15159508

Involvement in disease

Leigh syndrome (LS)

Subcellular Location

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.

Protein Families

Complex I 23 kDa subunit family

Tissue Specificity

Expressed in all tissues with the highest level in heart and skeletal muscle and the lowest level in lung.

Database Links

HGNC: 7715

OMIM: 256000

KEGG: hsa:4728

STRING: 9606.ENSP00000315774

UniGene: Hs.90443

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Oxidative Phosphorylation

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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