NDUFS8 Antibody

Code CSB-PA193298
Size US$166
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Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA193298(NDUFS8 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
  • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA193298(NDUFS8 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
  • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Jurkat cells, mouse heart tissue, Mouse brain tissue, Primary antibody: CSB-PA193298(NDUFS8 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds
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Product Details

Uniprot No.
Target Names
NDUFS8
Alternative Names
CI 23kD antibody; CI-23kD antibody; Complex I 23kD antibody; Complex I-23kD antibody; EC 1.6.5.3 antibody; EC 1.6.99.3 antibody; Human mitochondrial NADH dehydrogenase ubiquinone Fe S protein 8 antibody; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8; mitochondrial antibody; NADH ubiquinone oxidoreductase 23 kDa subunit antibody; NADH-ubiquinone oxidoreductase 23 kDa subunit antibody; NDUFS8 antibody; NDUS8_HUMAN antibody; TYKY antibody; TYKY subunit antibody; Ubiquinoneiron sulfur protein 8; mitochondrial precursor antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Fusion protein of Human NDUFS8
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
Antigen affinity purification
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form
Liquid
Tested Applications
ELISA,WB,IHC
Recommended Dilution
Application Recommended Dilution
ELISA 1:2000-1:5000
WB 1:500-1:2000
IHC 1:25-1:100
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
Gene References into Functions
  1. Results show that NDUFS8 protein and mRNA levels are up-regulated in lung neoplasm and correlate with poor overall survival. PMID: 27516145
  2. 2 new mutations (P85L upstream from the 2 cysteine motifs that coordinate the two [4Fe-4S] clusters which generate the complex I N2 clusters, & R138H between them)suggest that this subunit is essential for either the assembly or stability of complex I. PMID: 15159508
Involvement in disease
Leigh syndrome (LS)
Subcellular Location
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein Families
Complex I 23 kDa subunit family
Tissue Specificity
Expressed in all tissues with the highest level in heart and skeletal muscle and the lowest level in lung.
Database Links

HGNC: 7715

OMIM: 256000

KEGG: hsa:4728

STRING: 9606.ENSP00000315774

UniGene: Hs.90443

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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