NENF Antibody, Biotin conjugated

Datasheet
Code CSB-PA892354ND01HU
Size US$299
Uniprot No. Q9UMX5
Protocols ELISA Protocol
Immunogen Peptide sequence from Human Neudesin protein (149-167AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance Acts as a neurotrophic factor in postnatal mature neurons enhancing neuronal survival. Promotes cell proliferation and neurogenesis in undifferentiated neural pro-genitor cells at the embryonic stage and inhibits differentiation of astrocyte. Its neurotrophic activity is exerted via MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT pathways. Neurotrophic activity is enhanced by binding to heme. Acts also as an anorexigenic neurotrophic factor that contributes to energy balance (By similarity). Plays a role in the human tumorigenesis (PubMed:22748190).
Form Liquid
Conjugate Biotin
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method Antigen Affinity Purified
Isotype IgG
Clonality Polyclonal
Alias Neudesin (Cell immortalization-related protein 2) (Neuron-derived neurotrophic factor) (Protein GIG47) (Secreted protein of unknown function) (SPUF protein), NENF, CIR2 SPUF
Immunogen Species Homo sapiens (Human)
Research Area Neuroscience
Target Names NENF
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Acts as a neurotrophic factor in postnatal mature neurons enhancing neuronal survival. Promotes cell proliferation and neurogenesis in undifferentiated neural pro-genitor cells at the embryonic stage and inhibits differentiation of astrocyte. Its neurotrophic activity is exerted via MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT pathways. Neurotrophic activity is enhanced by binding to heme. Acts also as an anorexigenic neurotrophic factor that contributes to energy balance (By similarity). Plays a role in the human tumorigenesis
Subcellular Location Secreted, extracellular space
Protein Families Cytochrome b5 family, MAPR subfamily
Tissue Specificity Ubiquitously expressed with high expression in heart. Over-expressed in various tumors including carcinomas of the uterine cervix, lymphoma, colon, lung, skin and leukemia, as well as carcinoma of the breast.
Database Links

HGNC: 30384

OMIM: 611874

KEGG: hsa:29937

STRING: 9606.ENSP00000355955

UniGene: Hs.461787

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