NGEF Antibody, Biotin conjugated

Code CSB-PA850809LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) NGEF Polyclonal antibody
Uniprot No.
Target Names
NGEF
Alternative Names
ARHGEF27 antibody; Eph receptor-interacting exchange protein antibody; Eph-interacting exchange protein antibody; EPHEXIN antibody; Ephexin-1 antibody; Guanine nucleotide exchange factor, neuronal antibody; Neuronal guanine nucleotide exchange factor antibody; Ngef antibody; NGEF_HUMAN antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Ephexin-1 protein (495-710AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension.
Gene References into Functions
  1. A visceral-fat-associated SNP, rs11678490 of NGEF, was found in Korean men. PMID: 26340433
  2. FGFR-mediated phosphorylation of ephexin1 enhances the guanine nucleotide exchange activity toward RhoA without affecting the activity to Rac1 or Cdc42. PMID: 17702745
Subcellular Location
Cytoplasm. Membrane. Cell projection, growth cone.
Tissue Specificity
Highly expressed in brain specifically in caudate nucleus and to a lower extent in amygdala and hippocampus. Also detected in lung.
Database Links

HGNC: 7807

OMIM: 605991

KEGG: hsa:25791

STRING: 9606.ENSP00000264051

UniGene: Hs.97316

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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