NHP2 Antibody, HRP conjugated

Code CSB-PA873677LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) NHP2 Polyclonal antibody
Uniprot No.
Target Names
NHP2
Alternative Names
DKCB2 antibody; FLJ20479 antibody; H/ACA ribonucleoprotein complex subunit 2 antibody; NHP2 antibody; NHP2 like protein antibody; NHP2 ribonucleoprotein antibody; NHP2 ribonucleoprotein homolog (yeast) 1 antibody; NHP2 ribonucleoprotein homolog antibody; NHP2; S. cerevisiae; homolog of antibody; NHP2_HUMAN antibody; NHP2P antibody; NOLA2 antibody; Nucleolar protein family A member 2 (H/ACA small nucleolar RNPs) antibody; Nucleolar protein family A member 2 antibody; snoRNP protein NHP2 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human H/ACA ribonucleoprotein complex subunit 2 protein (1-153AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme.
Gene References into Functions
  1. In this work, we have uncovered a putative role of epigenetic regulation in a subset of human snoRNP complexes that are involved in the site-specific modification of RNA. We find that a subset of box C/D snoRNAs are methylated at the 1n position and that this blocks both 15.5k binding and the formation of the kinked conformation in vivo. PMID: 28623187
  2. Indian aplastic anemia patients did not have NHP2 mutations. PMID: 25906515
  3. Effects of dyskeratosis congenita mutations in NHP2 on assembly of H/ACA pre-RNPs PMID: 20008900
  4. NOLA2 expression in patients with squamous cell lung cancer increased by 70% which makes it a highly informative marker of squamous cell lung cancer PMID: 15889794
  5. The analysis of two other proteins, NHP2 and GAR1, that together with dyskerin and NOP10 are key components of telomerase and small nucleolar ribonucleoprotein (snoRNP) complexes, is described. PMID: 18523010

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Involvement in disease
Dyskeratosis congenita, autosomal recessive, 2 (DKCB2)
Subcellular Location
Nucleus, nucleolus. Nucleus, Cajal body. Note=Also localized to Cajal bodies (coiled bodies).
Protein Families
Eukaryotic ribosomal protein eL8 family
Tissue Specificity
Expressed in brain, colon, heart, kidney, ovary, pancreas, placenta, prostate, skeletal muscle, small intestine, spleen, testis and thymus. Also expressed at lower levels in the liver.
Database Links

HGNC: 14377

OMIM: 606470

KEGG: hsa:55651

STRING: 9606.ENSP00000274606

UniGene: Hs.744074

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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