NIT2 Antibody, HRP conjugated

Code CSB-PA882075LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) NIT2 Polyclonal antibody
Uniprot No.
Target Names
NIT2
Alternative Names
CUA002 antibody; MGC111199 antibody; NIT 2 antibody; Nit protein 2 antibody; NIT2 antibody; NIT2_HUMAN antibody; Nitrilase family member 2 antibody; Nitrilase homolog 2 antibody; Omega amidase NIT2 antibody; Omega-amidase NIT2 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Omega-amidase NIT2 protein (1-276AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Has omega-amidase activity. The role of omega-amidase is to remove potentially toxic intermediates by converting 2-oxoglutaramate and 2-oxosuccinamate to biologically useful 2-oxoglutarate and oxaloacetate, respectively.
Gene References into Functions
  1. Downregulation of NIT2 inhibits colon cancer cell proliferation and induces cell cycle arrest through the caspase-3 and PARP pathways PMID: 25738796
  2. Human NIT1/2 are not involved in the metabolism of vildagliptin. PMID: 25008847
  3. The activity and substrate specificity of human Nit2 was determined with alpha-ketoglutaramate and succinamate as substrates. PMID: 22674578
  4. Genotype analysis in 4 types of tumor tissue showed allelic imbalance surrounding NIT2 locus; results show that NIT2 plays an important role in cell growth inhibition & links to malignancies, suggesting Nit2 may be a potential tumor suppressor candidate PMID: 17488281
Subcellular Location
Cytoplasm.
Protein Families
Carbon-nitrogen hydrolase superfamily, NIT1/NIT2 family
Tissue Specificity
Detected in fetal brain (at protein level). Ubiquitous. Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, prostate, spleen, thymus, prostate, testis, ovary, small intestine and colon.
Database Links

HGNC: 29878

KEGG: hsa:56954

STRING: 9606.ENSP00000377696

UniGene: Hs.439152

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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