NIT2 Antibody

Datasheet

Code	CSB-PA882075LA01HU
Size	US$166
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Image	Western blot All lanes: NIT2 antibody at 3μg/ml Lane 1: Mouse heart tissue Lane 2: A549 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 31 kDa Observed band size: 31 kDa
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) NIT2 Polyclonal antibody

Uniprot No.

Q9NQR4

Target Names

NIT2

Alternative Names

CUA002 antibody; MGC111199 antibody; NIT 2 antibody; Nit protein 2 antibody; NIT2 antibody; NIT2_HUMAN antibody; Nitrilase family member 2 antibody; Nitrilase homolog 2 antibody; Omega amidase NIT2 antibody; Omega-amidase NIT2 antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human Omega-amidase NIT2 protein (1-276AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The NIT2 Antibody (Product code: CSB-PA882075LA01HU) is Non-conjugated. For NIT2 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA882075LB01HU	NIT2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA882075LC01HU	NIT2 Antibody, FITC conjugated
Biotin	CSB-PA882075LD01HU	NIT2 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Has omega-amidase activity. The role of omega-amidase is to remove potentially toxic intermediates by converting 2-oxoglutaramate and 2-oxosuccinamate to biologically useful 2-oxoglutarate and oxaloacetate, respectively.

Gene References into Functions

Downregulation of NIT2 inhibits colon cancer cell proliferation and induces cell cycle arrest through the caspase-3 and PARP pathways PMID: 25738796
Human NIT1/2 are not involved in the metabolism of vildagliptin. PMID: 25008847
The activity and substrate specificity of human Nit2 was determined with alpha-ketoglutaramate and succinamate as substrates. PMID: 22674578
Genotype analysis in 4 types of tumor tissue showed allelic imbalance surrounding NIT2 locus; results show that NIT2 plays an important role in cell growth inhibition & links to malignancies, suggesting Nit2 may be a potential tumor suppressor candidate PMID: 17488281

Subcellular Location

Cytoplasm.

Protein Families

Carbon-nitrogen hydrolase superfamily, NIT1/NIT2 family

Tissue Specificity

Detected in fetal brain (at protein level). Ubiquitous. Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, prostate, spleen, thymus, prostate, testis, ovary, small intestine and colon.

Database Links

HGNC: 29878

KEGG: hsa:56954

STRING: 9606.ENSP00000377696

UniGene: Hs.439152

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Target Therapy

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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