NLGN1 Antibody

Code CSB-PA839786LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA839786LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA839786LA01HU at dilution of 1:100

  • Immunofluorescent analysis of MCF-7 cells using CSB-PA839786LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) NLGN1 Polyclonal antibody
Uniprot No.
Target Names
NLGN1
Alternative Names
NLG 1 antibody; KIAA1070 antibody; MGC45115 antibody; Neuroligin-1 antibody; NL1 antibody; NLG1 antibody; Nlgn1 antibody; NLGN1_HUMAN antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Neuroligin-1 protein (51-300AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The NLGN1 Antibody (Product code: CSB-PA839786LA01HU) is Non-conjugated. For NLGN1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA839786LB01HU NLGN1 Antibody, HRP conjugated ELISA
FITC CSB-PA839786LC01HU NLGN1 Antibody, FITC conjugated
Biotin CSB-PA839786LD01HU NLGN1 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Required to maintain wakefulness quality and normal synchrony of cerebral cortex activity during wakefulness and sleep. The protein is involved in nervous system development.
Gene References into Functions
  1. Findings support a contribution of the NLGN1 gene pathway to the neurobiological underpinnings of PTSD. PMID: 27219346
  2. We show that a novel NLGN1 Pro89Leu (P89L) missense variant found in two autism spectrum disorder (ASD) siblings leads to changes in cellular localization, protein degradation, and to the impairment of spine formation. Furthermore, we generated the knock-in P89L mice, and we show that the P89L heterozygote mice display abnormal social behavior, a core feature of ASD PMID: 28841651
  3. the expression of NL1 and its binding partner neurexin-1beta was increased in temporal lobe epileptic foci in patients and lithium-pilocarpine-treated epileptic rats. PMID: 25428619
  4. Neuroligin 1 (NL1) promotes the formation of glutamatergic synapses and mediates long-term potentiation. PMID: 26440732
  5. NLGN1 was associated with schizophrenia in Chinese Han Populations PMID: 26674772
  6. Increasing expression of TGF-beta1 protein, decreasing expressions of Ghrelin, Neurexin, and Neuroligin proteins can induce the loss or dysfunction of ganglion cells in distal intestinal canal PMID: 25399301
  7. Neuroligin-1 and Glu may represent new markers of ganglion cells, whose expression may correlate with the pathogenesis, diagnosis, differential diagnosis or classification of Hirschsprung's disease. PMID: 26109803
  8. Results indicate that the neurexin and neuroligin synaptic complex is intrinsically involved in the regulation of DISC1 function, thus contributing to a better understanding of the pathology of schizophrenia. PMID: 26078884
  9. Monitoring the attachment and detachment of neurexin (Nrx)-coated quantum dots measures the rates of neurexin (Nrx)/neuroligin interaction in the hippocampus. PMID: 23853109
  10. We identified a cluster of single nucleotide polymorphisms at the NLGN1 locus showing significant association with BP variability. Follow-up analyses did not support an association with risk of ischemic stroke and its subtypes PMID: 23929743
  11. Expression levels of neurexin and neuroligin in ENS are significantly down-regulated in HSCR, which may be involved in the pathogenesis of HSCR. PMID: 23264101
  12. these manipulations of NL1 function illuminate the significance of NL1 intracellular signaling in vivo, and enhance our understanding of the factors that gate the maturation of glutamatergic synapses and complex behavior PMID: 23719805
  13. Amyloid beta-peptide binds to the extracellular domain of neuroligin-1 with a K(d) in the nanomolar range. PMID: 21838267
  14. glycosylation processing of neuroligin, in addition to mRNA splicing and gene selection, contributes to the specificity of the neurexin-beta/neuroligin-1 association PMID: 14522992
  15. the neurexin 1beta/neuroligin 1 complex has a role in synapse formation PMID: 15797875
  16. Our discoveries provide insight into the specific interaction of the GOPC PDZ domain with the C-terminal peptide of Nlg and also provide a general insight about the possible binding mode of the interaction of Nlg with other PDZ domain-containing proteins. PMID: 16882988
  17. Neuroligin-1 performs diverse synaptic functions by mechanisms that include as essential components of alpha-neurexin binding and neuroligin dimerization, but extend beyond these activities. PMID: 19730411

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Subcellular Location
Cell membrane; Single-pass type I membrane protein. Cell junction, synapse, postsynaptic density. Cell junction, synapse, synaptic cleft. Cell junction, synapse, synaptic cell membrane.
Protein Families
Type-B carboxylesterase/lipase family
Tissue Specificity
Expressed in the blood vessel walls (at protein level). Highly expressed in brain through prenatal stages, and at lower levels in pancreas islet beta cells.
Database Links

HGNC: 14291

OMIM: 600568

KEGG: hsa:22871

STRING: 9606.ENSP00000354541

UniGene: Hs.478289

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