NLRC4 Antibody

Code CSB-PA873615ESR1HU
Size US$167Purchase it in Cusabio online store
(only available for customers from the US)
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  • Immunohistochemistry of paraffin-embedded human colon tissue using CSB-PA873615ESR1HU at dilution of 1:100

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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) NLRC4 Polyclonal antibody
Uniprot No. Q9NPP4
Target Names NLRC4
Alternative Names and NACHT-containing protein antibody; CARD 12 antibody; CARD antibody; CARD LRR and NACHT containing protein 1 antibody; CARD LRR and NACHT containing protein antibody; CARD12 antibody; Caspase recruitment domain containing protein 12 antibody; Caspase recruitment domain family member 12 antibody; Caspase recruitment domain-containing protein 12 antibody; CLAN 1 antibody; CLAN A antibody; CLAN antibody; CLAN B antibody; CLAN C antibody; CLAN D antibody; Clan protein antibody; CLAN1 antibody; CLANA antibody; CLANB antibody; CLANC antibody; CLAND antibody; CLR 2.1 antibody; CLR2.1 antibody; ICE protease activating factor antibody; Ice protease-activating factor antibody; Ipaf antibody; LRR antibody; NLR family CARD domain containing 4 antibody; NLR family CARD domain-containing protein 4 antibody; NLRC 4 antibody; NLRC4 antibody; NLRC4_HUMAN antibody; NOD like receptor C4 antibody; Nucleotide binding oligomerization domain leucine rich repeat and CARD domain containing 4 antibody; UNQ6189/PRO20215 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human NLR family CARD domain-containing protein 4 protein (1-250AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Antigen Affinity purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form Liquid
Tested Applications ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
(From Uniprot)
Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis.
Gene References into Functions
  1. Study findings suggest that NLRC4 may be involved in the exacerbation or modification of psoriatic lesions. PMID: 29797527
  2. Cryo-EM structures of ASC and NLRC4 CARD filaments reveal a unified mechanism of nucleation and activation of caspase-1 PMID: 30279182
  3. obesity-associated NLRC4 inflammasome activation/ interleukin-1 signalling promotes breast cancer progression in humans and in mouse models PMID: 27708283
  4. this study shows that human NAIP-NLRC4-inflammasome senses the Pseudomonas aeruginosa T3SS inner-rod protein PMID: 28992059
  5. mRNA expression levels of NLRP1 and NLRC4 were not altered in chronic hepatitis B patients, suggesting that these genes are not responsible for the impaired immune responses against HBV observed in these patients. PMID: 27750030
  6. The authors describe a novel mutation in NLRC4 in a large pedigree causing an NLRC4-associated, partially anakinra-responsive AID, dominated by cutaneous erythematous nodes and urticarial rash, arthralgias, and late-onset enterocolitis. PMID: 27203668
  7. Results found that NLRC4 expression increased in for promoting DN progression and demonstrate NLRC4-driven IL-1beta production as critical for the progression of DN. PMID: 27706238
  8. Ubiquitin-tagged NLRC4 could induce cell death and activate caspase-8 independent of Ser(533) phosphorylation. Our PMID: 27974463
  9. LPS activates the MAPK pathway in macrophages, thus resulting in the upregulation of NLRC4; however, NLRC4 inhibits IL1beta and IL18 production, contributing to the anti-inflammatory response. PMID: 27175981
  10. High expression of NLRP3, NLRC4, and CASP1 in background non-tumorous liver is significantly correlated with poor prognosis of patients after resection of hepatocellular carcinoma. PMID: 28011505
  11. association of IL-18 levels with a single nucleotide polymorphism in the untranslated exon 2 of the inflammasome component NLRC4 PMID: 26362438
  12. While both contributing to pathogen clearance, NLRP3 more than NLRC4 contributes to deleterious inflammatory responses in cystic fibrosis and correlates with defective NLRC4-dependent IL-1Ra production. PMID: 26972847
  13. analysis of a subset of inflammasome receptors including NLRP3, NLRC4 and AIM2 that triggers formation of the micrometer-sized spherical supramolecular complex called the ASC speck PMID: 26258904
  14. Thus, pathogenic inflammasome activity during Candida infection is negatively regulated by the IL-22/NLRC4/IL-1Ra axis. PMID: 26269955
  15. cN-II co-immunoprecipitated both with wild type Ipaf and its LRR domain after transfection with corresponding expression vectors, but not with Ipaf lacking the LRR domain. PMID: 25811392
  16. Elevated expression of IPAF was associated with inflammation in patients with pemphigus vulgaris disease. PMID: 25342284
  17. Data indicate that NLR family CARD domain containing 4 protein (NLRC4) is a causative gene for familial cold autoinflammatory syndrome (FCAS). PMID: 25385754
  18. Data show that the disease was caused by a de novo gain-of-function mutation in NLR family CARD domain containing 4 (NLRC4) encoding a p.Val341Ala substitution. PMID: 25217960
  19. inflammasome (also known as NLRC4) has been demonstrated to play a role in host defense mechanisms against pathogen-associated molecules PMID: 24054992
  20. This review describes the surprisingly diverse mechanisms by which NLRC4 senses bacteria and initiates innate immune responses. PMID: 23215645
  21. the NAIP5-NLRC4 inflammasome is induced by direct interactions with conserved N- and C-terminal regions of flagellin PMID: 23012363
  22. NLRC4 is important for host survival and bacterial clearance, as well as neutrophil-mediated inflammation in the lungs following Klebsiella pneumoniae infection. PMID: 22547706
  23. Twelve single nucleotide polymorphisms within NLRP1, NLRP3, NLRC4, CARD8, CASP1, and IL1B genes were analyzed in 150 HIV-1-infected Brazilian subjects. PMID: 22227487
  24. Genetic analysis of Chromobacterium violaceum infection revealed that the TTSS needle protein CprI can stimulate NLRC4 inflammasome activation in human macrophages PMID: 21918512
  25. [review] role of NLRC4 inflammasome and pathways in innate immune detection of bacterial virulence factors PMID: 20349122
  26. Apaf-1 protein expression did not correlate with Apaf-1 mRNA levels in human leukaemic blasts.Apaf-1 DNA promoter methylation might contribute to the inactivation of Apaf-1 expression PMID: 12545166
  27. CLAN regulates several events central to host defense mechanisms against invading bacteria: modulating relative sensitivity of macrophages to lipopolysaccharide and peptidoglycan, and impacting host-pathogen interactions. PMID: 15528373
  28. p53 can directly induce Ipaf gene transcription, which contributes to p53-dependent apoptosis in at least some human cells PMID: 15580302
  29. Involvement of caspase 1 and its activator Ipaf upstream of mitochondrial events in apoptosis PMID: 16817903
  30. hNAIP and hIpaf mediate innate intracellular defense against flagellated Legionella in human cells. PMID: 18453601

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Involvement in disease Autoinflammation with infantile enterocolitis (AIFEC); Familial cold autoinflammatory syndrome 4 (FCAS4)
Subcellular Location Cytoplasm, Cytoplasm, cytosol
Tissue Specificity Isoform 2 is expressed ubiquitously, although highly expressed in lung and spleen. Isoform 1 is highly expressed in lung, followed by leukocytes especially monocytes, lymph node, colon, brain, prostate, placenta, spleen, bone marrow and fetal liver. Isofo
Database Links

HGNC: 16412

OMIM: 606831

KEGG: hsa:58484

STRING: 9606.ENSP00000354159

UniGene: Hs.574741

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