NLRP1 Antibody

Datasheet
Code CSB-PA015864GA01HU
Product Type Purified Rabbit Anti human PolyClonal Antibody
Size US$685
Uniprot No. Q9C000
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunogen Human NLRP1
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA,IHC
Storage Buffer PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method Antigen Affinity Purified
Isotype IgG
Alias NLR family, pyrin domain containing 1;NLRP1;CARD7;CLR17.1;DEFCAP;DEFCAP-L/S;DKFZp586O1822;KIAA0926;NAC;NALP1;PP1044;SLEV1;VAMAS1 ;
Immunogen Species Homo sapiens (Human)
Target Names NLRP1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Details This gene encodes a member of the Ced-4 family of apoptosis proteins. Ced-family members contain a caspase recruitment domain (CARD) and are known to be key mediators of programmed cell death. The encoded protein contains a distinct N-terminal pyrin-like motif, which is possibly involved in protein-protein interactions. This protein interacts strongly with caspase 2 and weakly with caspase 9. Overexpression of this gene was demonstrated to induce apoptosis in cells. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined.
HGNC 14374
RGD 1310963
MGI 2684861
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Function As the sensor component of the NLRP1 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP1, CASP1, and possibly PYCARD. Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. Activation of NLRP1 inflammasome is also required for HMGB1 secretion. The active cytokines and HMGB1 stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death
Involvement in disease Vitiligo-associated multiple autoimmune disease 1 (VAMAS1); Palmoplantar carcinoma, multiple self-healing (MSPC); Autoinflammation with arthritis and dyskeratosis (AIADK)
Subcellular Location Cytoplasm, cytosol, Cytoplasm, Inflammasome, Nucleus
Protein Families NLRP family
Tissue Specificity Widely expressed (PubMed:11113115, PubMed:17164409). Abundantly expressed in primary immune cells (isoform 1 and isoform 2), including in neutrophils, monocytes/macrophages, dendritic cells (mostly Langerhans cells), and B- and T-lymphocytes (at protein l
Database Links

HGNC: 14374

OMIM: 606579

KEGG: hsa:22861

STRING: 9606.ENSP00000460475

UniGene: Hs.652273

Pathway Inflammasome Signaling
NOD-like receptor signaling pathway

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